Shin-Ichi Higashijima
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Explore the profile of Shin-Ichi Higashijima including associated specialties, affiliations and a list of published articles.
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81
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3572
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Recent Articles
1.
Shimizu S, Katayama T, Nishiumi N, Tanimoto M, Kimura Y, Higashijima S
Zoological Lett
. 2025 Jan;
11(1):1.
PMID: 39754210
In vertebrates, skeletal muscle comprises fast and slow fibers. Slow and fast muscle cells in fish are spatially segregated; slow muscle cells are located only in a superficial region, and...
2.
Zhu Y, Gelnaw H, Leary P, Raghuraman R, Kamath N, Kraja A, et al.
bioRxiv
. 2024 Oct;
PMID: 39464026
Patients with tauopathies present with profoundly different clinical symptoms , even within the same disorder . A central hypothesis in the field, well-supported by biomarker studies and post-mortem pathology ,...
3.
Hamling K, Harmon K, Kimura Y, Higashijima S, Schoppik D
J Neurosci
. 2024 May;
44(30.
PMID: 38777599
Mature vertebrates maintain posture using vestibulospinal neurons that transform sensed instability into reflexive commands to spinal motor circuits. Postural stability improves across development. However, due to the complexity of terrestrial...
4.
Tanimoto Y, Kakinuma H, Aoki R, Shiraki T, Higashijima S, Okamoto H
Cell Rep
. 2024 Mar;
43(3):113916.
PMID: 38484735
The cortico-basal ganglia circuit mediates decision making. Here, we generated transgenic tools for adult zebrafish targeting specific subpopulations of the components of this circuit and utilized them to identify evolutionary...
5.
Hamling K, Harmon K, Kimura Y, Higashijima S, Schoppik D
bioRxiv
. 2023 Dec;
PMID: 38105966
Mature vertebrates maintain posture using vestibulospinal neurons that transform sensed instability into reflexive commands to spinal motor circuits. Postural stability improves across development. However, due to the complexity of terrestrial...
6.
Pallucchi I, Bertuzzi M, Madrid D, Fontanel P, Higashijima S, El Manira A
Nat Neurosci
. 2023 Nov;
27(1):78-89.
PMID: 37919423
The flexibility of motor actions is ingrained in the diversity of neurons and how they are organized into functional circuit modules, yet our knowledge of the molecular underpinning of motor...
7.
Miyadai M, Takada H, Shiraishi A, Kimura T, Watakabe I, Kobayashi H, et al.
Development
. 2023 Oct;
150(19).
PMID: 37823232
Neural crest cells generate numerous derivatives, including pigment cells, and are a model for studying how fate specification from multipotent progenitors is controlled. In mammals, the core gene regulatory network...
8.
Sugioka T, Tanimoto M, Higashijima S
Nat Commun
. 2023 Mar;
14(1):1217.
PMID: 36898983
Land-walking vertebrates maintain a desirable posture by finely controlling muscles. It is unclear whether fish also finely control posture in the water. Here, we showed that larval zebrafish have fine...
9.
Ma M, Brunal A, Clark K, Studtmann C, Stebbins K, Higashijima S, et al.
Front Cell Dev Biol
. 2023 Mar;
11:1113675.
PMID: 36875755
The corticotropin-releasing hormone (CRH)-expressing neurons in the hypothalamus are critical regulators of the neuroendocrine stress response pathway, known as the hypothalamic-pituitary-adrenal (HPA) axis. As developmental vulnerabilities of CRH neurons contribute...
10.
Laureano A, Flaherty K, Hinman A, Jadali A, Nakamura T, Higashijima S, et al.
Biol Open
. 2023 Jan;
11(12).
PMID: 36594417
Homeobox genes act at the top of genetic hierarchies to regulate cell specification and differentiation during embryonic development. We identified the short stature homeobox domain 2 (shox2) transcription factor that...