Shih Chieh Chang
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Explore the profile of Shih Chieh Chang including associated specialties, affiliations and a list of published articles.
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10
Citations
247
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Recent Articles
1.
Targeted degradation of PCNA outperforms stoichiometric inhibition to result in programed cell death
Chang S, Gopal P, Lim S, Wei X, Chandramohan A, Mangadu R, et al.
Cell Chem Biol
. 2022 Nov;
29(11):1601-1615.e7.
PMID: 36318925
Biodegraders are targeted protein degradation constructs composed of mini-proteins/peptides linked to E3 ligase receptors. We gained deeper insights into their utility by studying Con1-SPOP, a biodegrader against proliferating cell nuclear...
2.
Ng S, Lim S, Sim A, Mangadu R, Lau A, Zhang C, et al.
Sci Rep
. 2022 Aug;
12(1):14087.
PMID: 35982220
Immune checkpoint blockade (ICB) leads to durable and complete tumour regression in some patients but in others gives temporary, partial or no response. Accordingly, significant efforts are underway to identify...
3.
Her Z, Tan J, Lim Y, Tan S, Chan X, Tan W, et al.
Front Immunol
. 2020 Oct;
11:580968.
PMID: 33013934
Non-alcoholic fatty liver disease (NAFLD) has been on a global rise. While animal models have rendered valuable insights to the pathogenesis of NAFLD, discrepancy with patient data still exists. Since...
4.
Ong S, Bajaj S, Tanner M, Chang S, Krishnarjuna B, Ng X, et al.
ACS Pharmacol Transl Sci
. 2020 Aug;
3(4):720-736.
PMID: 32832873
We describe a cysteine-rich, membrane-penetrating, joint-targeting, and remarkably stable peptide, EgK5, that modulates voltage-gated K1.3 potassium channels in T lymphocytes by a distinctive mechanism. EgK5 enters plasma membranes and binds...
5.
Lim S, Khoo R, Peh K, Teo J, Chang S, Ng S, et al.
Proc Natl Acad Sci U S A
. 2020 Mar;
117(11):5791-5800.
PMID: 32123106
Targeted degradation approaches such as proteolysis targeting chimeras (PROTACs) offer new ways to address disease through tackling challenging targets and with greater potency, efficacy, and specificity over traditional approaches. However,...
6.
Pennington M, Chang S, Chauhan S, Huq R, Tajhya R, Chhabra S, et al.
Mar Drugs
. 2015 Jan;
13(1):529-42.
PMID: 25603346
ShK, from the sea anemone Stichodactyla helianthus, is a 35-residue disulfide-rich peptide that blocks the voltage-gated potassium channel Kv1.3 at ca. 10 pM and the related channel Kv1.1 at ca....
7.
Sher I, Chang S, Li Y, Chhabra S, Palmer 3rd A, Norton R, et al.
Chembiochem
. 2014 Sep;
15(16):2402-10.
PMID: 25236806
ShK is a 35-residue peptide that binds with high affinity to human voltage-gated potassium channels through a conserved K-Y dyad. Here we have employed NMR measurements of backbone-amide (15)N spin-relaxation...
8.
Chhabra S, Chang S, Nguyen H, Huq R, Tanner M, Londono L, et al.
FASEB J
. 2014 Jun;
28(9):3952-64.
PMID: 24891519
The voltage-gated potassium (Kv) 1.3 channel is widely regarded as a therapeutic target for immunomodulation in autoimmune diseases. ShK-186, a selective inhibitor of Kv1.3 channels, ameliorates autoimmune diseases in rodent...
9.
Rashid M, Heinzelmann G, Huq R, Tajhya R, Chang S, Chhabra S, et al.
PLoS One
. 2013 Nov;
8(11):e78712.
PMID: 24244345
The voltage-gated potassium channel Kv1.3 is a well-established target for treatment of autoimmune diseases. ShK peptide from a sea anemone is one of the most potent blockers of Kv1.3 but...
10.
Chang S, Galea C, Leung E, Tajhya R, Beeton C, Pennington M, et al.
Toxicon
. 2012 Jun;
60(5):840-50.
PMID: 22659540
The polypeptide toxin ShK is a potent blocker of Kv1.3 potassium channels, which play a crucial role in the activation of human effector memory T-cells (T(EM)). Selective blockers constitute valuable...