Shih-Shun Chen
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Explore the profile of Shih-Shun Chen including associated specialties, affiliations and a list of published articles.
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29
Citations
342
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Recent Articles
1.
Hsu P, Chen C, Tsai H, Chang W, Pei J, Wang Y, et al.
In Vivo
. 2024 Dec;
39(1):152-159.
PMID: 39740875
Background/aim: Genetic polymorphisms in DNA repair mechanisms can modulate overall DNA repair capacity, potentially influencing individual susceptibility to cancer. This study investigated the relationship between polymorphic variations in DNA ligase...
2.
Hung C, Tsai C, Chin Y, Wang Y, Liu C, Lin M, et al.
Cancer Genomics Proteomics
. 2024 Aug;
21(5):502-510.
PMID: 39191502
Background/aim: Matrix metalloproteinase-2 (MMP-2) has been implicated in the pathogenesis of breast cancer (BC). However, there is limited research on the role of MMP-2 genotypes in BC risk. This study...
3.
Chen C, Tien N, Yao C, Chen S, Bau D, Pandey S, et al.
Environ Toxicol
. 2024 Jul;
39(11):5059-5073.
PMID: 39056589
Naringin, a bioflavonoid compound from grapefruit or citrus, exerts anticancer activities on cervical, thyroid, colon, brain, liver, lung, thyroid, and breast cancers. The present investigation addressed exploring the anticancer effects...
4.
Hung K, Tien N, Bau D, Yao C, Chen C, Yang J, et al.
Cells
. 2023 Sep;
12(18).
PMID: 37759534
The aberrant activation of signaling pathways contributes to cancer cells with metabolic reprogramming. Thus, targeting signaling modulators is considered a potential therapeutic strategy for cancer. Subcellular fractionation, coimmunoprecipitation, biochemical analysis,...
5.
Wang W, Hsu Y, Lin M, Chen S, Lai Y, Huang C, et al.
Bioengineering (Basel)
. 2023 Aug;
10(8).
PMID: 37627791
Tricalcium phosphate (TCP) has gained attention due to its interconnected porous structures which promote fibrovascular invasion and bony replacement. Moreover, when gelatin is added and crosslinked with genipin (GGT), TCP...
6.
Chang J, Tien N, Chang Y, Lin M, Chen S
Cells
. 2021 Jun;
10(6).
PMID: 34064109
Targeting the activities of endoplasmic reticulum (ER)-mitochondrial-dependent metabolic reprogramming is considered one of the most promising strategies for cancer treatment. Here, we present biochemical subcellular fractionation, coimmunoprecipitation, gene manipulation, and...
7.
Wu C, Wang S, Lee C, Chan W, Lin M, Chen S
Int J Mol Sci
. 2020 Aug;
21(16).
PMID: 32823607
Pharmacologic intervention to affect the membrane lipid homeostasis of lipid rafts is a potent therapeutic strategy for cancer. Here we showed that gallic acid (GA) caused the complex formation of...
8.
Lee T, Wang S, Chan W, Lee C, Wu T, Lin M, et al.
Cells
. 2020 Feb;
9(2).
PMID: 32033487
The specialized cholesterol/sphingolipid-rich membrane domains termed lipid rafts are highly dynamic in the cancer cells, which rapidly assemble effector molecules to form a sorting platform essential for oncogenic signaling transduction...
9.
Wu C, Wang S, Lin M, Chen S
Eur J Pharmacol
. 2019 May;
855:137-148.
PMID: 31059711
Selective pharmacologic targeting of cell cycle regulators is a potent anti-cancer therapeutic strategy. Here, we show that caspase-3-mediated p21 cleavage involves p53 independent of triptolide (TPL)-induced S phase arrest in...
10.
Hung K, Wang S, Lin M, Chen S
Int J Mol Sci
. 2019 May;
20(9).
PMID: 31035650
Citrate is a key intermediate of the tricarboxylic acid cycle and acts as an allosteric signal to regulate the production of cellular ATP. An elevated cytosolic citrate concentration inhibits growth...