Shigeru Hishinuma
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Explore the profile of Shigeru Hishinuma including associated specialties, affiliations and a list of published articles.
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37
Citations
181
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Recent Articles
1.
Koyama Y, Hamada Y, Fukui Y, Hosogi N, Fujimoto R, Hishinuma S, et al.
Glia
. 2024 Aug;
72(12):2231-2246.
PMID: 39166289
Na-K-2Cl cotransporter-1 (NKCC1) is present in brain cells, including astrocytes. The expression of astrocytic NKCC1 increases in the acute phase of traumatic brain injury (TBI), which induces brain edema. Endothelin-1...
2.
Michinaga S, Hishinuma S, Koyama Y
Vitam Horm
. 2024 Jul;
126:97-111.
PMID: 39029978
Sonic hedgehog (Shh) is a secreted glycopeptide belonging to the hedgehog family that is essential for morphogenesis during embryonic development. The Shh signal is mediated by two membrane proteins, Patched-1...
3.
Michinaga S, Nagata A, Ogami R, Ogawa Y, Hishinuma S
Int J Mol Sci
. 2024 Mar;
25(6).
PMID: 38542369
Arrestins are known to be involved not only in the desensitization and internalization of G protein-coupled receptors but also in the G protein-independent activation of mitogen-activated protein (MAP) kinases, such...
4.
Michinaga S, Nagata A, Ogami R, Ogawa Y, Hishinuma S
Biochem Pharmacol
. 2023 May;
213:115595.
PMID: 37201878
G protein-coupled histamine H receptors play crucial roles in allergic and inflammatory reactions, in which the phosphorylation of extracellular signal-regulated kinase (ERK) appears to mediate the production of inflammatory cytokines....
5.
Michinaga S, Hishinuma S, Koyama Y
Cells
. 2023 Mar;
12(5).
PMID: 36899860
Traumatic brain injury (TBI) is an intracranial injury caused by accidents, falls, or sports. The production of endothelins (ETs) is increased in the injured brain. ET receptors are classified into...
6.
Michinaga S, Sonoda K, Inazuki N, Ezaki M, Awane H, Shimizu K, et al.
J Pharmacol Sci
. 2022 Oct;
150(3):135-145.
PMID: 36184118
Histamine is a major neurotransmitter and alleviates neuronal damage after ischemic injury via H receptors. Herein, we investigated the effects of H receptor agonists on the blood-brain barrier (BBB) disruption...
7.
Michinaga S, Onishi K, Shimizu K, Mizuguchi H, Hishinuma S
Biol Pharm Bull
. 2021 Nov;
44(11):1759-1766.
PMID: 34719652
Vasogenic edema results from blood-brain barrier (BBB) disruption after traumatic brain injury (TBI), and although it can be fatal, no promising therapeutic drugs have been developed as yet. Transient receptor...
8.
Akimoto H, Uesawa Y, Hishinuma S
Int J Mol Sci
. 2021 Mar;
22(5).
PMID: 33673686
The binding affinity of ligands for their receptors is determined by their kinetic and thermodynamic binding properties. Kinetic analyses of the rate constants of association and dissociation ( and ,...
9.
Akimoto H, Sugihara M, Hishinuma S
Int J Mol Sci
. 2021 Feb;
22(4).
PMID: 33562121
Bilastine, a zwitterionic second-generation antihistamine containing a carboxyl group, has higher selectivity for H receptors than first-generation antihistamines. Ligand-receptor docking simulations have suggested that the electrostatic interaction between the carboxyl...
10.
Kobayashi C, Tanaka A, Yasuda T, Hishinuma S
Biochem Pharmacol
. 2020 Aug;
180:114185.
PMID: 32738199
Docking simulations based on the crystal structure of human histamine H receptors have predicted crucial roles of Lys191 and Lys179, which exist at the entrance of the ligand-binding pocket, in...