Sherry Xi Chen
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Explore the profile of Sherry Xi Chen including associated specialties, affiliations and a list of published articles.
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5
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196
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Recent Articles
1.
Wu L, Dai P, Wang M, Chen S, Cohen E, Jayachandran G, et al.
Nat Commun
. 2022 Apr;
13(1):1791.
PMID: 35379811
Current gold standard for absolute quantitation of a specific DNA sequence is droplet digital PCR (ddPCR), which has been applied to copy number variation (CNV) detection. However, the number of...
2.
Dai P, Wu L, Chen S, Wang M, Cheng L, Zhang J, et al.
Nat Commun
. 2021 Oct;
12(1):6123.
PMID: 34675197
Quantitation of rare somatic mutations is essential for basic research and translational clinical applications including minimal residual disease (MRD) detection. Though unique molecular identifier (UMI) has suppressed errors for rare...
3.
Chen S, Seelig G
J Am Chem Soc
. 2016 Mar;
138(15):5076-86.
PMID: 27010123
Even a single-nucleotide difference between the sequences of two otherwise identical biological nucleic acids can have dramatic functional consequences. Here, we use model-guided reaction pathway engineering to quantitatively improve the...
4.
Chen S, Zhang D, Seelig G
Nat Chem
. 2013 Aug;
5(9):782-9.
PMID: 23965681
Small variations in nucleic acid sequences can have far-reaching phenotypic consequences. Reliably distinguishing closely related sequences is therefore important for research and clinical applications. Here, we demonstrate that conditionally fluorescent...
5.
Zhang D, Chen S, Yin P
Nat Chem
. 2012 Feb;
4(3):208-14.
PMID: 22354435
The specific hybridization of complementary sequences is an essential property of nucleic acids, enabling diverse biological and biotechnological reactions and functions. However, the specificity of nucleic acid hybridization is compromised...