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Shelley L Baumgardt

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Recent Articles
1.
Baumgardt S, Fang J, Fu X, Liu Y, Xia Z, Zhao M, et al.
Cardiovasc Res . 2024 Jul; 120(12):1456-1471. PMID: 39001869
Aims: The histone deacetylase 6 (HDAC6) inhibitor, tubastatin A (TubA), reduces myocardial ischaemia/reperfusion injury (MIRI) in type 1 diabetic rats. It remains unclear whether HDAC6 regulates MIRI in type 2...
2.
Baumgardt S, Fang J, Fu X, Liu Y, Xia Z, Zhao M, et al.
bioRxiv . 2023 Mar; PMID: 36865233
Background: Diabetes augments activity of histone deacetylase 6 (HDAC6) and generation of tumor necrosis factor α (TNFα) and impairs the physiological function of mitochondrial complex I (mCI) which oxidizes reduced...
3.
Liu Y, Paterson M, Baumgardt S, Irwin M, Xia Z, Bosnjak Z, et al.
Cardiovasc Res . 2018 Jun; 115(1):168-178. PMID: 29931049
Aims: Previous studies indicate that nitric oxide derived from endothelial nitric oxide synthase (eNOS) serves as both trigger and mediator in anaesthetic cardiac preconditioning. The mechanisms underlying regulation of eNOS...
4.
Liu Y, Baumgardt S, Fang J, Shi Y, Qiao S, Bosnjak Z, et al.
Sci Rep . 2017 Jun; 7(1):3093. PMID: 28596578
GTP cyclohydrolase 1 (GCH1) and its product tetrahydrobiopterin play crucial roles in cardiovascular health and disease, yet the exact regulation and role of GCH1 in adverse cardiac remodeling after myocardial...
5.
Wu H, Baumgardt S, Fang J, Paterson M, Liu Y, Du J, et al.
Sci Rep . 2016 Jun; 6:27925. PMID: 27295516
Diabetic cardiomyopathy increases the risk of heart failure and death. At present, there are no effective approaches to preventing its development in the clinic. Here we report that reduction of...
6.
Baumgardt S, Paterson M, Leucker T, Fang J, Zhang D, Bosnjak Z, et al.
Circ Heart Fail . 2016 Jan; 9(1):e002424. PMID: 26763290
Background: Diabetic heart disease is associated with tetrahydrobiopterin oxidation and high arginase activity, leading to endothelial nitric oxide synthase dysfunction. Sepiapterin (SEP) is a tetrahydrobiopterin precursor, and L-citrulline (L-Cit) is...