Sheila Higginbotham
Overview
Explore the profile of Sheila Higginbotham including associated specialties, affiliations and a list of published articles.
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7
Citations
221
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Recent Articles
1.
Saeed M, Higginbotham S, Gaikwad N, Chakravarti D, Rogan E, Cavalieri E
Free Radic Biol Med
. 2009 Jul;
47(7):1075-81.
PMID: 19619639
Naphthalene has been shown to be a weak carcinogen in rats. To investigate its mechanism of metabolic activation and cancer initiation, mice were topically treated with naphthalene or one of...
2.
Chakravarti D, Venugopal D, Mailander P, Meza J, Higginbotham S, Cavalieri E, et al.
Mutat Res
. 2007 Oct;
649(1-2):161-78.
PMID: 17931959
Polycyclic aromatic hydrocarbons (PAH) form stable and depurinating DNA adducts in mouse skin to induce preneoplastic mutations. Some mutations transform cells, which then clonally expand to establish tumors. Strong clues...
3.
Saeed M, Higginbotham S, Rogan E, Cavalieri E
Chem Biol Interact
. 2007 Jan;
165(3):175-88.
PMID: 17224140
Naphthalene is considered by the US Environmental Protection Agency to be a carcinogenic compound based on inhalation studies in rats. The primary metabolite of naphthalene is naphthalene 1,2-arene oxide. This...
4.
Mailander P, Meza J, Higginbotham S, Chakravarti D
J Steroid Biochem Mol Biol
. 2006 Sep;
101(4-5):204-15.
PMID: 16982187
Evidence suggests that the genotoxic mechanism of estrogens (estrone/estradiol) in breast cancer involves their oxidation to 3,4-quinones and reaction with DNA to form depurinating N3Ade and N7Gua adducts. We examined...
5.
Saeed M, Gunselman S, Higginbotham S, Rogan E, Cavalieri E
Steroids
. 2004 Dec;
70(1):37-45.
PMID: 15610895
The nonsteroidal synthetic estrogen hexestrol (HES), which is diethylstilbestrol hydrogenated at the C-3-C-4 double bond, is carcinogenic. Its major metabolite is the catechol, 3'-OH-HES, which can be metabolically converted to...
6.
Li K, Todorovic R, Devanesan P, Higginbotham S, Kofeler H, Ramanathan R, et al.
Carcinogenesis
. 2003 Oct;
25(2):289-97.
PMID: 14578156
Studies of estrogen metabolism, formation of DNA adducts, carcinogenicity, cell transformation and mutagenicity have led to the hypothesis that reaction of certain estrogen metabolites, predominantly catechol estrogen-3,4-quinones, with DNA can...
7.
Cavalieri E, Li K, Balu N, Saeed M, Devanesan P, Higginbotham S, et al.
Carcinogenesis
. 2002 Jun;
23(6):1071-7.
PMID: 12082031
Catechol estrogens and catecholamines are metabolized to quinones, and the metabolite catechol (1,2-dihydroxybenzene) of the leukemogenic benzene can also be oxidized to its quinone. We report here that quinones obtained...