Shawn Fernando
Overview
Explore the profile of Shawn Fernando including associated specialties, affiliations and a list of published articles.
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Articles
8
Citations
100
Followers
0
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Recent Articles
1.
Furuuchi K, Rybinski K, Fulmer J, Moriyama T, Drozdowski B, Soto A, et al.
Cancer Sci
. 2021 Mar;
112(6):2467-2480.
PMID: 33756060
The antibody-drug conjugate (ADC) MORAb-202, consisting of farletuzumab paired with a cathepsin B-cleavable linker and eribulin, targets folate receptor alpha (FRA), which is frequently overexpressed in various tumor types. MORAb-202...
2.
Cheng X, Li J, Tanaka K, Majumder U, Milinichik A, Verdi A, et al.
Mol Cancer Ther
. 2018 Sep;
17(12):2665-2675.
PMID: 30262588
Microtubule-targeting agents (MTA) have been investigated for many years as payloads for antibody-drug conjugates (ADC). In many cases, these ADCs have shown limited benefits due to lack of efficacy or...
3.
Kline J, Fernando S, Ross E, Grasso L, Nicolaides N
Eur J Immunol
. 2018 Aug;
48(11):1872-1882.
PMID: 30144039
C1q-engagement with IgG and IgM type antibodies is the initiating step of classical complement-mediated immunity. The tumor shed antigen CA125 has been reported to have immunosuppressive effects on host tumor...
4.
Nicolaides N, Schweizer C, Somers E, Wang W, Fernando S, Ross E, et al.
Cancer Biol Ther
. 2018 Apr;
19(7):622-630.
PMID: 29652548
The tumor-shed antigen CA125 has recently been found to bind certain monoclonal antibodies (mAbs) and suppress immune-effector mediated killing through perturbation of the Fc domain with CD16a and CD32a Fc-γ ...
5.
Kline J, Kennedy R, Albone E, Chao Q, Fernando S, McDonough J, et al.
Oncotarget
. 2017 Sep;
8(32):52045-52060.
PMID: 28881712
Cancers employ a number of mechanisms to evade host immune responses. Here we report the effects of tumor-shed antigen CA125/MUC16 on suppressing IgG1-mediated antibody-dependent cellular cytotoxicity (ADCC). This evidence stems...
6.
Rybinski K, Imtiyaz H, Mittica B, Drozdowski B, Fulmer J, Furuuchi K, et al.
Oncotarget
. 2015 Sep;
6(28):25429-40.
PMID: 26327620
Over-expression of endosialin/CD248 (herein referred to as CD248) has been associated with increased tumor microvasculature in various tissue origins which makes it an attractive anti-angiogenic target. In an effort to...
7.
Irwin J, Wali T, Fernando S, Schleyer T
AMIA Annu Symp Proc
. 2008 Aug;
:987.
PMID: 18694087
Based on the morbidity and mortality due to oral cancer, it is essential that oral cancer information available on the Internet be usable, organized and credible. We evaluated the information...
8.
Irwin J, Fernando S, Schleyer T, Spallek H
Stud Health Technol Inform
. 2007 Oct;
129(Pt 2):1127-31.
PMID: 17911891
Speech recognition allows clinicians a hands-free option for interacting with computers, which is important for dentists who have difficulty using a keyboard and a mouse when working with patients. While...