Shaun A Summers
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Explore the profile of Shaun A Summers including associated specialties, affiliations and a list of published articles.
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28
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728
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Recent Articles
1.
Ford S, OSullivan K, Kitching A, Holdsworth S, Gan P, Summers S
Int J Mol Sci
. 2023 Jan;
24(2).
PMID: 36674855
ANCA-associated vasculitis (AAV) is intricately linked with infections. Toll-like receptors (TLR) provide a potential link between infection and anti-myeloperoxidase (MPO) autoimmunity. TLR9 ligation has been shown to promote anti-MPO autoimmunity...
2.
Grynberg K, Polkinghorne K, Ford S, Stenning F, Lew T, Barrett J, et al.
BMC Nephrol
. 2017 Mar;
18(1):93.
PMID: 28302078
Background: Acute Kidney Injury (AKI) is a well recognized complication of cardiac surgery. It is associated with significant morbidity and mortality. The aims of our study are twofold; 1. To...
3.
Gan P, OSullivan K, Ooi J, Alikhan M, Odobasic D, Summers S, et al.
J Am Soc Nephrol
. 2015 Sep;
27(5):1321-33.
PMID: 26374606
Observations in experimental murine myeloperoxidase (MPO)-ANCA-associated vasculitis (AAV) show mast cells degranulate, thus enhancing injury as well as producing immunomodulatory IL-10. Here we report that, compared with biopsy specimens from...
4.
OSullivan K, Lo C, Summers S, Elgass K, McMillan P, Longano A, et al.
Kidney Int
. 2015 Jul;
88(5):1030-46.
PMID: 26176828
Myeloperoxidase (MPO) is an important neutrophil lysosomal enzyme, a major autoantigen, and a potential mediator of tissue injury in MPO-ANCA-associated vasculitis (MPO-AAV) and glomerulonephritis. Here we examined MPO deposition in...
5.
Alikhan M, Summers S, Gan P, Chan A, Khouri M, Ooi J, et al.
J Am Soc Nephrol
. 2015 Jun;
27(3):706-14.
PMID: 26116356
Toll-like receptor 9 (TLR9) enhances proinflammatory responses, but whether it can act in a regulatory capacity remains to be established. In experimental murine AKI induced by cisplatin, Tlr9(-/-) mice developed...
6.
Walsh S, Summers S, Amlot P, Sheaff M, Neild G
NDT Plus
. 2015 May;
1(5):313-5.
PMID: 25983921
We present a case of post-transplantation Kaposi's sarcoma (KS) successfully treated by conversion to rapamycin. Clinical and histological resolution was observed within 6 months of commencing rapamycin. Also, vascular endothelial...
7.
Odobasic D, Muljadi R, OSullivan K, Kettle A, Dickerhof N, Summers S, et al.
Arthritis Rheumatol
. 2015 Mar;
67(7):1868-80.
PMID: 25777776
Objective: Myeloperoxidase (MPO) locally contributes to organ damage in various chronic inflammatory conditions by generating reactive intermediates. The contribution of MPO in the development of experimental lupus is unknown. The...
8.
Tesch G, Sourris K, Summers S, McCarthy D, Ward M, Borg D, et al.
Diabetologia
. 2014 Jun;
57(9):1977-85.
PMID: 24957662
Aims/hypothesis: The AGEs and the receptor for AGEs (RAGE) are known contributors to diabetic complications. RAGE also has a physiological role in innate and adaptive immunity and is expressed on...
9.
Chan A, Alikhan M, Odobasic D, Gan P, Khouri M, Steinmetz O, et al.
Am J Pathol
. 2014 Mar;
184(5):1411-8.
PMID: 24631024
In acute kidney injury, which is a significant cause of morbidity and mortality, cytokines and leukocytes promote inflammation and injury. We examined the pathogenic role of IL-17A in cisplatin-induced acute...
10.
Ford S, Polkinghorne K, Longano A, Dowling J, Dayan S, Kerr P, et al.
Am J Kidney Dis
. 2013 Nov;
63(2):227-35.
PMID: 24183110
Background: A predictive histologic classification recently was proposed to determine the prognostic value of kidney biopsy in patients with antineutrophil cytoplasmic antibody-associated renal vasculitis (AAV). Study Design: A dual-purpose retrospective...