Sharon Vinsant
Overview
Explore the profile of Sharon Vinsant including associated specialties, affiliations and a list of published articles.
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11
Citations
574
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Recent Articles
1.
Vinsant S, Mansfield C, Jimenez-Moreno R, Gaizo Moore V, Yoshikawa M, Hampton T, et al.
Brain Behav
. 2014 Jan;
3(4):431-57.
PMID: 24381813
Pathological events are well characterized in amyotrophic lateral sclerosis (ALS) mouse models, but review of the literature fails to identify a specific initiating event that precipitates disease pathology. There is...
2.
Vinsant S, Mansfield C, Jimenez-Moreno R, Gaizo Moore V, Yoshikawa M, Hampton T, et al.
Brain Behav
. 2014 Jan;
3(4):335-50.
PMID: 24381807
Charcot first described amyotrophic lateral sclerosis (ALS) in 1869; however, its causes remain largely unknown and effective, long-term treatment strategies are not available. The first mouse model of ALS was...
3.
Jung A, Kim T, Rhyu I, Kim H, Lee Y, Vinsant S, et al.
J Neurosci
. 2008 Mar;
28(11):2941-8.
PMID: 18337425
During early postnatal development, the orchestrated regulation of proliferation, migration and the survival versus elimination of neurons is essential for histogenesis of the cerebellum. For instance, Purkinje cells (PCs) promote...
4.
Oppenheim R, Blomgren K, Ethell D, Koike M, Komatsu M, Prevette D, et al.
J Neurosci
. 2008 Feb;
28(6):1490-7.
PMID: 18256270
Previous studies have shown that caspases and Apaf-1 are required for the normal programmed cell death (PCD) in vivo of immature postmitotic neurons and mitotically active neuronal precursor cells. In...
5.
Kim W, Kim Y, Eun B, Park O, Kim H, Kim K, et al.
J Neurosci
. 2007 Dec;
27(52):14392-403.
PMID: 18160647
Rats and mice exhibit neurogenesis of olfactory bulb (OB) interneurons throughout adulthood. To homeostatically maintain stable neuron numbers, it is necessary to continuously remove a subset of OB neurons by...
6.
Buss R, Gould T, Ma J, Vinsant S, Prevette D, Winseck A, et al.
J Neurosci
. 2006 Dec;
26(52):13413-27.
PMID: 17192424
The widespread, massive loss of developing neurons in the central and peripheral nervous system of birds and mammals is generally considered to be an evolutionary adaptation. However, until recently, models...
7.
Discoordinate regulation of renal nitric oxide synthase isoforms in ovariectomized mRen2. Lewis rats
Yamaleyeva L, Gallagher P, Vinsant S, Chappell M
Am J Physiol Regul Integr Comp Physiol
. 2006 Oct;
292(2):R819-26.
PMID: 17023669
Estrogen depletion markedly exacerbates hypertension in female congenic mRen2. Lewis rats, a model of tissue renin overexpression. Because estrogen influences nitric oxide synthase (NOS) and NO may exert differential effects...
8.
Gould T, Buss R, Vinsant S, Prevette D, Sun W, Knudson C, et al.
J Neurosci
. 2006 Aug;
26(34):8774-86.
PMID: 16928866
The death of cranial and spinal motoneurons (MNs) is believed to be an essential component of the pathogenesis of amyotrophic lateral sclerosis (ALS). We tested this hypothesis by crossing Bax-deficient...
9.
Sun W, Winseck A, Vinsant S, Park O, Kim H, Oppenheim R
J Neurosci
. 2004 Dec;
24(49):11205-13.
PMID: 15590937
In the dentate gyrus (DG) of the adult mouse hippocampus, a substantial number of new cells are generated daily, but only a subset of these survive and differentiate into mature...
10.
Neuromuscular development after the prevention of naturally occurring neuronal death by Bax deletion
Sun W, Gould T, Vinsant S, Prevette D, Oppenheim R
J Neurosci
. 2003 Aug;
23(19):7298-310.
PMID: 12917363
The removal of excess neurons by programmed cell death (PCD) is believed to be critical for the proper development and function of the nervous system. A major role of this...