Sharon E Mitchell
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Explore the profile of Sharon E Mitchell including associated specialties, affiliations and a list of published articles.
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76
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Recent Articles
1.
Xia F, Wu Y, Li M, Mitchell S, Speakman J
J Gerontol A Biol Sci Med Sci
. 2024 Dec;
PMID: 39715339
Calorie restriction (CR) extends lifespan and prevents several aging related diseases. During short-term restriction, we previously showed that lean tissues generally decrease in size, but the alimentary tract (especially the...
2.
Mitchell S, Simpson M, Coulet L, Gouedard S, Hambly C, Morimoto J, et al.
Proc Natl Acad Sci U S A
. 2024 Oct;
121(42):e2408682121.
PMID: 39374394
The disposable soma theory (DST) posits that organisms age and die because of a direct trade-off in resource allocation between reproduction and somatic maintenance. DST predicts that investments in reproduction...
3.
Smith Jr D, Mitchell S, Johnson M, Gibbs V, Dickinson S, Henschel B, et al.
Geroscience
. 2024 Jun;
46(5):4809-4826.
PMID: 38850387
Caloric restriction (CR) results in reduced energy and protein intake, raising questions about protein restriction's contribution to CR longevity benefits. We kept ad libitum (AL)-fed male C57BL/6J mice at 27°C...
4.
Osorio M J, Mitchell S, Hambly C, Allison D, Speakman J
Appetite
. 2024 May;
200:107421.
PMID: 38759755
Dietary protein modulates food intake (FI) via unclear mechanism(s). One possibility is that higher protein leads to greater post-ingestive heat production (Specific dynamic action: SDA) leading to earlier meal termination...
5.
Semercioz-Oduncuoglu A, Mitchell S, Ozilgen M, Yilmaz B, Speakman J
Proc Natl Acad Sci U S A
. 2023 Sep;
120(37):e2300624120.
PMID: 37669389
Understanding aging is a key biological goal. Precision gerontology aims to predict how long individuals will live under different treatment scenarios. Calorie and protein restriction (CR and PR) extend lifespan...
6.
Mitchell S, Togo J, Green C, Derous D, Hambly C, Speakman J
J Gerontol A Biol Sci Med Sci
. 2023 Jun;
78(11):1953-1963.
PMID: 37354128
Calorie restriction (CR) typically promotes a reduction in body mass, which correlates with increased lifespan. We evaluated the overall changes in survival, body mass dynamics, and body composition following long-term...
7.
Wang L, Derous D, Huang X, Mitchell S, Douglas A, Lusseau D, et al.
J Gerontol A Biol Sci Med Sci
. 2023 Feb;
78(7):1125-1134.
PMID: 36757838
Calorie restriction (CR) extends life span by modulating the mechanisms involved in aging. We quantified the hepatic proteome of male C57BL/6 mice exposed to graded levels of CR (0%-40% CR)...
8.
Krol E, Turner F, Derous D, Mitchell S, Martin S, Douglas A, et al.
J Comp Physiol B
. 2023 Jan;
193(2):171-192.
PMID: 36650338
Peak lactation occurs when milk production is at its highest. The factors limiting peak lactation performance have been subject of intense debate. Milk production at peak lactation appears limited by...
9.
Phillips D, Mathers H, Mitchell S, Speakman J
J Gerontol A Biol Sci Med Sci
. 2022 May;
77(10):1994-2001.
PMID: 35639808
Calorie restriction (CR) without malnutrition increases the health and life span of diverse taxa. The mechanism(s) behind CR are debated but may be directly linked to body composition changes that...
10.
Garcia-Flores L, Green C, Mitchell S, Promislow D, Lusseau D, Douglas A, et al.
Proc Natl Acad Sci U S A
. 2021 Jul;
118(31).
PMID: 34330829
The evolutionary context of why caloric restriction (CR) activates physiological mechanisms that slow the process of aging remains unclear. The main goal of this analysis was to identify, using metabolomics,...