Shankara Narayanan Varadarajan
Overview
Explore the profile of Shankara Narayanan Varadarajan including associated specialties, affiliations and a list of published articles.
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10
Citations
30
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Recent Articles
1.
Jancy S, Lupitha S, Chandrasekharan A, Varadarajan S, Nelson-Sathi S, Prasad R, et al.
Biol Proced Online
. 2023 Jul;
25(1):22.
PMID: 37495994
Background: The entry of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) into the host cell is mediated through the binding of the SARS-CoV-2 Spike protein via the receptor binding domain...
2.
Chandrasekharan A, Varadarajan S, Lekshmi A, Santhoshkumar T
Free Radic Biol Med
. 2022 Nov;
194:33-41.
PMID: 36427748
Cytosolic and organelle redox are highly interrelated, and their alterations play critical roles in both physiological and pathological cell states. This highly regulated process is crucial in life-death decisions of...
3.
Lupitha S, Darvin P, Chandrasekharan A, Varadarajan S, Divakaran S, Easwaran S, et al.
Antib Ther
. 2022 Apr;
5(2):100-110.
PMID: 35437514
Quantitative determination of neutralizing antibodies against Severe Acute Respiratory Syndrome Corona Virus-2 (SARS-CoV-2) is paramount in immunodiagnostics, vaccine efficacy testing, and immune response profiling among the vaccinated population. Cost-effective, rapid,...
4.
Varadarajan S, Mathew K, Chandrasekharan A, Lupitha S, Lekshmi A, Mini M, et al.
J Cell Biochem
. 2022 Feb;
123(4):782-797.
PMID: 35106828
Cancer cells grown as 3D-structures are better models for mimicking in vivo conditions than the 2D-culture systems employable in drug discovery applications. Cell cycle and cell death are important determinants...
5.
Darvin P, Chandrasekharan A, Varadarajan S, Chandrasekhar L, Maliakkal R, S M J, et al.
Photodiagnosis Photodyn Ther
. 2020 Jul;
31:101921.
PMID: 32679191
Background: Photodynamic therapy (PDT) is a successful cancer treatment modality. In vitro, in vivo, and clinical studies with different photosensitizers reveal diverging cell fates, including apoptosis, necrosis, autophagy, and non-specific...
6.
Lupitha S, Chandrasekhar L, Varadarajan S, Jayaprasad A, Chandrasekharan A, Patil S, et al.
Toxicol Lett
. 2020 Feb;
326:23-30.
PMID: 32109534
Simultaneous detection of autophagy and apoptosis is important in drug discovery and signaling studies. Here we report, a real-time reporter cell line for the simultaneous detection of apoptosis and autophagy...
7.
Chandrasekharan A, Varadarajan S, Lekshmi A, Lupitha S, Darvin P, Chandrasekhar L, et al.
Redox Biol
. 2018 Nov;
20:379-389.
PMID: 30408753
Most toxic compounds including cancer drugs target mitochondria culminating in its permeabilization. Cancer drug-screening and toxicological testing of compounds require cost-effective and sensitive high-throughput methods to detect mitochondrial damage. Real-time...
8.
Lekshmi A, Varadarajan S, Lupitha S, Nair M, Chandrasekharan A, Santhoshkumar T
Curr Protoc Toxicol
. 2018 Mar;
75:2.27.1-2.27.16.
PMID: 29512126
Recent cell biology studies reveal that a cell can die through multiple pathways via distinct signaling mechanisms. Among these, apoptosis and necrosis are two distinct cell death pathways, and their...
9.
Indira D, Varadarajan S, Lupitha S, Lekshmi A, Mathew K, Chandrasekharan A, et al.
Eur J Cell Biol
. 2017 Nov;
97(1):1-14.
PMID: 29092745
The selective autophagic removal of mitochondria called mitophagy is an essential physiological signaling for clearing damaged mitochondria and thus maintains the functional integrity of mitochondria and cells. Defective mitophagy is...
10.
Lekshmi A, Varadarajan S, Lupitha S, Indira D, Mathew K, Chandrasekharan Nair A, et al.
Cell Death Discov
. 2017 Feb;
3:16101.
PMID: 28179996
Apoptosis and necrosis are the two major forms of cell death mechanisms. Both forms of cell death are involved in several physiological and pathological conditions and also in the elimination...