Shankar Srinivas
Overview
Explore the profile of Shankar Srinivas including associated specialties, affiliations and a list of published articles.
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54
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1740
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Recent Articles
1.
Thowfeequ S, Hanna C, Srinivas S
Nat Rev Mol Cell Biol
. 2024 Dec;
PMID: 39627419
Extraembryonic tissues have pivotal roles in morphogenesis and patterning of the early mammalian embryo. Developmental programmes mediated through signalling pathways and gene regulatory networks determine the sequence in which fate...
2.
Williams R, Taylor G, Ling I, Candido-Ferreira I, Fountain D, Mayes S, et al.
PLoS Biol
. 2024 Oct;
22(10):e3002786.
PMID: 39418292
Neurocristopathies such as CHARGE syndrome result from aberrant neural crest development. A large proportion of CHARGE cases are attributed to pathogenic variants in the gene encoding CHD7, chromodomain helicase DNA...
3.
Thowfeequ S, Fiorentino J, Hu D, Solovey M, Ruane S, Whitehead M, et al.
Dev Cell
. 2024 Jun;
59(17):2347-2363.e9.
PMID: 38843837
The anterior visceral endoderm (AVE) differs from the surrounding visceral endoderm (VE) in its migratory behavior and ability to restrict primitive streak formation to the opposite side of the mouse...
4.
Lubatti G, Stock M, Iturbide A, Ruiz Tejada Segura M, Riepl M, Tyser R, et al.
Development
. 2023 Jun;
150(11).
PMID: 37294170
A powerful feature of single-cell genomics is the possibility of identifying cell types from their molecular profiles. In particular, identifying novel rare cell types and their marker genes is a...
5.
Thowfeequ S, Srinivas S
Philos Trans R Soc Lond B Biol Sci
. 2022 Oct;
377(1865):20210255.
PMID: 36252217
The first few days of embryonic development in eutherian mammals are dedicated to the specification and elaboration of the extraembryonic tissues. However, where the fetus ends and its adnexa begins...
6.
Sheng G, Boroviak T, Schmidt-Ott U, Srinivas S
Philos Trans R Soc Lond B Biol Sci
. 2022 Oct;
377(1865):20210250.
PMID: 36252213
No abstract available.
7.
Mau K, Karimlou D, Barneda D, Brochard V, Royer C, Leeke B, et al.
Nat Commun
. 2022 Jul;
13(1):3861.
PMID: 35790717
Mammalian pre-implantation embryos accumulate substantial lipids, which are stored in lipid droplets (LDs). Despite the fundamental roles of lipids in many cellular functions, the significance of building-up LDs for the...
8.
Tyser R, Srinivas S
Semin Cell Dev Biol
. 2022 May;
131:35-43.
PMID: 35606274
Gastrulation is a fundamental process during embryonic development, conserved across all multicellular animals [1]. In the majority of metazoans, gastrulation is characterised by large scale morphogenetic remodeling, leading to the...
9.
Royer C, Sandham E, Slee E, Schneider F, Lagerholm C, Godwin J, et al.
Nat Commun
. 2022 Feb;
13(1):941.
PMID: 35177595
During development, pseudostratified epithelia undergo large scale morphogenetic events associated with increased mechanical stress. Using a variety of genetic and imaging approaches, we uncover that in the mouse E6.5 epiblast,...
10.
Thowfeequ S, Stower M, Srinivas S
Curr Opin Genet Dev
. 2021 Dec;
72:110-117.
PMID: 34929609
The first epithelia to arise in an organism face the challenge of maintaining the integrity of the newly formed tissue, while exhibiting the behavioral flexibility required for morphogenetic processes to...