Shankar Gopinath
Overview
Explore the profile of Shankar Gopinath including associated specialties, affiliations and a list of published articles.
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Articles
33
Citations
1037
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Recent Articles
1.
McGinnis J, Ortiz-Guzman J, Mallannagari S, Guevara M, Belfort B, Bao S, et al.
bioRxiv
. 2025 Jan;
PMID: 39763930
It is becoming more broadly accepted that human-based models are needed to better understand the complexities of the human nervous system and its diseases. The recently developed human brain organotypic...
2.
McGinnis J, Ortiz-Guzman J, Guevara M, Mallannagari S, Belfort B, Bao S, et al.
bioRxiv
. 2024 Nov;
PMID: 39605617
The development of cell-type-specific gene therapy vectors for treating neurological diseases holds great promise, but has relied on animal models with limited translational utility. We have adapted an organotypic model...
3.
Yue J, Etemad L, Elguindy M, van Essen T, Belton P, Nelson L, et al.
Trauma Surg Acute Care Open
. 2024 Jul;
9(1):e001501.
PMID: 39081460
Abstract: Objectives: An estimated 14-23% of patients with traumatic brain injury (TBI) incur multiple lifetime TBIs. The relationship between prior TBI and outcomes in patients with moderate to severe TBI...
4.
Bryant A, Rose N, Temkin N, Barber J, Manley G, McCrea M, et al.
JAMA Netw Open
. 2023 Dec;
6(12):e2349118.
PMID: 38147333
Importance: Cognitive dysfunction is common after traumatic brain injury (TBI), with a well-established dose-response relationship between TBI severity and likelihood or magnitude of persistent cognitive impairment. However, patterns of cognitive...
5.
Roberts C, Barber J, Temkin N, Dong A, Robertson C, Valadka A, et al.
JAMA Surg
. 2023 Dec;
159(3):248-259.
PMID: 38091011
Importance: Traumatic brain injury (TBI) is associated with persistent functional and cognitive deficits, which may be susceptible to secondary insults. The implications of exposure to surgery and anesthesia after TBI...
6.
Katlowitz K, Gopinath S, Cruz Navarro J, Robertson C
Neurotherapeutics
. 2023 Jun;
20(6):1538-1545.
PMID: 37351829
Traumatic brain injuries (TBIs) are associated with high morbidity and mortality due to both the original insult as well as the destructive biological response that follows. Medical management aims to...
7.
8.
Burke J, Gugger J, Ding K, Kim J, Foreman B, Yue J, et al.
JAMA Netw Open
. 2021 Dec;
4(12):e2140191.
PMID: 34964854
Importance: Posttraumatic epilepsy (PTE) is a recognized sequela of traumatic brain injury (TBI), but the long-term outcomes associated with PTE independent of injury severity are not precisely known. Objective: To...
9.
Yuh E, Jain S, Sun X, Pisica D, Harris M, Taylor S, et al.
JAMA Neurol
. 2021 Jul;
78(9):1137-1148.
PMID: 34279565
Importance: A head computed tomography (CT) with positive results for acute intracranial hemorrhage is the gold-standard diagnostic biomarker for acute traumatic brain injury (TBI). In moderate to severe TBI (Glasgow...
10.
McCrea M, Giacino J, Barber J, Temkin N, Nelson L, Levin H, et al.
JAMA Neurol
. 2021 Jul;
78(8):982-992.
PMID: 34228047
Importance: Moderate to severe traumatic brain injury (msTBI) is a major cause of death and disability in the US and worldwide. Few studies have enabled prospective, longitudinal outcome data collection...