Shangtao Liu
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Explore the profile of Shangtao Liu including associated specialties, affiliations and a list of published articles.
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8
Citations
1551
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Recent Articles
1.
Simoneau A, Pratt C, Wu H, Rajeswaran S, Comer C, Sudsakorn S, et al.
Mol Cancer Ther
. 2025 Jan;
PMID: 39886906
Inhibition of the deubiquitinating enzyme USP1 can induce synthetic lethality in tumors characterized by homologous recombination deficiency (HRD) and represents a novel therapeutic strategy for the treatment of BRCA1/2 mutant...
2.
Zhao H, Gui W, Liu S, Zhao F, Fan W, Jing F, et al.
Front Nutr
. 2024 Sep;
11:1451481.
PMID: 39309139
Background: Sex hormones are crucial for the development of children and adolescents. The increasing consumption of ultra-processed foods (UPFs) among children and adolescents in the United States (US) has raised...
3.
Simoneau A, Engel J, Bandi M, Lazarides K, Liu S, Meier S, et al.
Mol Cancer Ther
. 2022 Oct;
22(2):215-226.
PMID: 36228090
CRISPR Cas9-based screening is a powerful approach for identifying and characterizing novel drug targets. Here, we elucidate the synthetic lethal mechanism of deubiquitinating enzyme USP1 in cancers with underlying DNA...
4.
Meyer A, Saaem I, Silverman A, Varaljay V, Mickol R, Blum S, et al.
ACS Synth Biol
. 2019 Nov;
8(12):2746-2755.
PMID: 31750651
Organism engineering requires the selection of an appropriate chassis, editing its genome, combining traits from different source species, and controlling genes with synthetic circuits. When a strain is needed for...
5.
Lieber D, Calvo S, Shanahan K, Slate N, Liu S, Hershman S, et al.
Neurology
. 2013 Apr;
80(19):1762-70.
PMID: 23596069
Objective: To evaluate the utility of targeted exome sequencing for the molecular diagnosis of mitochondrial disorders, which exhibit marked phenotypic and genetic heterogeneity. Methods: We considered a diverse set of...
6.
Calvo S, Compton A, Hershman S, Lim S, Lieber D, Tucker E, et al.
Sci Transl Med
. 2012 Jan;
4(118):118ra10.
PMID: 22277967
Advances in next-generation sequencing (NGS) promise to facilitate diagnosis of inherited disorders. Although in research settings NGS has pinpointed causal alleles using segregation in large families, the key challenge for...
7.
Lieber D, Vafai S, Horton L, Slate N, Liu S, Borowsky M, et al.
BMC Med Genet
. 2012 Jan;
13:3.
PMID: 22226368
Background: Mitochondrial diseases comprise a diverse set of clinical disorders that affect multiple organ systems with varying severity and age of onset. Due to their clinical and genetic heterogeneity, these...
8.
Talkowski M, Ernst C, Heilbut A, Chiang C, Hanscom C, Lindgren A, et al.
Am J Hum Genet
. 2011 Apr;
88(4):469-81.
PMID: 21473983
The contribution of balanced chromosomal rearrangements to complex disorders remains unclear because they are not detected routinely by genome-wide microarrays and clinical localization is imprecise. Failure to consider these events...
9.
Clark A, Eisen M, Smith D, Bergman C, Oliver B, Markow T, et al.
Nature
. 2007 Nov;
450(7167):203-18.
PMID: 17994087
Comparative analysis of multiple genomes in a phylogenetic framework dramatically improves the precision and sensitivity of evolutionary inference, producing more robust results than single-genome analyses can provide. The genomes of...