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Shane English

Explore the profile of Shane English including associated specialties, affiliations and a list of published articles. Areas
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Articles 41
Citations 948
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Cook D, Taneja S, Krewulak K, Zytaruk N, Menon K, Fowler R, et al.
JAMA Netw Open . 2024 Jul; 7(7):e2420458. PMID: 38995645
Importance: The COVID-19 pandemic created unprecedented challenges for clinical trials worldwide, threatening premature closure and trial integrity. Every phase of research operations was affected, often requiring modifications to protocol design...
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Cook D, Deane A, Lauzier F, Zytaruk N, Guyatt G, Saunders L, et al.
N Engl J Med . 2024 Jun; 391(1):9-20. PMID: 38875111
Background: Whether proton-pump inhibitors are beneficial or harmful for stress ulcer prophylaxis in critically ill patients undergoing invasive ventilation is unclear. Methods: In this international, randomized trial, we assigned critically...
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DAragon F, Selzner M, Breau R, Masse M, Lamontagne F, Masse M, et al.
BMJ Open . 2024 Jun; 14(6):e086777. PMID: 38871657
Introduction: Most solid organ transplants originate from donors meeting criteria for death by neurological criteria (DNC). Within the organ donor, physiological responses to brain death increase the risk of ischaemia...
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Dennis B, Deane A, Lauzier F, Zytaruk N, Hardie M, Hammond N, et al.
BMC Med Res Methodol . 2024 May; 24(1):109. PMID: 38704520
Background: During the COVID-19 pandemic, many intensive care units (ICUs) halted research to focus on COVID-19-specific studies. Objective: To describe the conduct of an international randomized trial of stress ulcer...
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Rahman M, Charbonney E, Vaisler R, Khalifa A, Alhazzani W, Gossack-Keenan K, et al.
Can J Anaesth . 2024 Mar; 71(8):1137-1144. PMID: 38504038
Purpose: The ordering of routine blood test panels in advance is common in intensive care units (ICUs), with limited consideration of the pretest probability of finding abnormalities. This practice contributes...
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Heels-Ansdell D, Billot L, Thabane L, Alhazzani W, Deane A, Guyatt G, et al.
Trials . 2023 Dec; 24(1):796. PMID: 38057875
Background: The REVISE (Re-Evaluating the Inhibition of Stress Erosions in the ICU) trial will evaluate the impact of the proton pump inhibitor pantoprazole compared to placebo in invasively ventilated critically...
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Deane A, Alhazzani W, Guyatt G, Finfer S, Marshall J, Myburgh J, et al.
BMJ Open . 2023 Nov; 13(11):e075588. PMID: 37968012
Introduction: The e-aluating the nhibition of tress rosions (REVISE) Trial aims to determine the impact of the proton pump inhibitor pantoprazole compared with placebo on clinically important upper gastrointestinal (GI)...
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Shaw J, Ouyang Y, Fergusson D, McArdle T, Martin C, Cook D, et al.
JMIR Res Protoc . 2023 Oct; 12:e51783. PMID: 37801356
Background: Normal saline (NS) and Ringer's lactate (RL) are the most common crystalloids given to hospitalized patients. Despite concern about possible harm associated with NS (eg, hyperchloremic metabolic acidosis, impaired...
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Dennis B, Thabane L, Heels-Ansdell D, Dionne J, Binnie A, Tsang J, et al.
Trials . 2023 Aug; 24(1):561. PMID: 37644556
Background: Critically ill patients commonly receive proton pump inhibitors (PPIs) to prevent gastrointestinal (GI) bleeding from stress-induced ulceration. Despite widespread use in the intensive care unit (ICU), observational data suggest...