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» Authors » Shabnam Sircaik

Shabnam Sircaik

Explore the profile of Shabnam Sircaik including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 8
Citations 78
Followers 0
Related Specialties
Microbiology
Cell Biology
Science
Top 10 Co-Authors
Richard J Bennett
Iuliana V Ene
Pallavi Kakade
Jesus Pla
David R Andes
Shen-Huan Liang
Joseph Dainis
Edwina Thomas
Sneh L Panwar
Sneh Lata Panwar
Published In
Cell Microbiol
FEMS Yeast Res
Proc Natl Acad Sci U S A
bioRxiv
PLoS Pathog
Affiliations
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Recent Articles
1.
An IL-17-DUOX2 axis controls gastrointestinal colonization by
Kakade P, Burgueno J, Sircaik S, Ponde N, Li J, Ene I, et al.
bioRxiv . 2024 Sep; PMID: 39229022
is a ubiquitous fungus in the human gut microbiome as well as a prevalent cause of opportunistic mucosal and systemic disease. There is currently little understanding, however, as to how...
2.
The hyphal-specific toxin candidalysin promotes fungal gut commensalism
Liang S, Sircaik S, Dainis J, Kakade P, Penumutchu S, McDonough L, et al.
Nature . 2024 Mar; 627(8004):620-627. PMID: 38448595
The fungus Candida albicans frequently colonizes the human gastrointestinal tract, from which it can disseminate to cause systemic disease. This polymorphic species can transition between growing as single-celled yeast and...
3.
Filamentation and biofilm formation are regulated by the phase-separation capacity of network transcription factors in Candida albicans
Ganser C, Staples M, Dowell M, Frazer C, Dainis J, Sircaik S, et al.
PLoS Pathog . 2023 Dec; 19(12):e1011833. PMID: 38091321
The ability of the fungus Candida albicans to filament and form biofilms contributes to its burden as a leading cause of hospital-acquired infections. Biofilm development involves an interconnected transcriptional regulatory...
4.
Aneuploidy and gene dosage regulate filamentation and host colonization by
Kakade P, Sircaik S, Maufrais C, Ene I, Bennett R
Proc Natl Acad Sci U S A . 2023 Mar; 120(11):e2218163120. PMID: 36893271
Aneuploidy is a frequent occurrence in fungal species where it can alter gene expression and promote adaptation to a variety of environmental cues. Multiple forms of aneuploidy have been observed...
5.
The protein kinase Ire1 impacts pathogenicity of Candida albicans by regulating homeostatic adaptation to endoplasmic reticulum stress
Sircaik S, Roman E, Bapat P, Lee K, Andes D, Gow N, et al.
Cell Microbiol . 2021 Jan; 23(5):e13307. PMID: 33403715
The unfolded protein response (UPR), crucial for the maintenance of endoplasmic reticulum (ER) homeostasis, is tied to the regulation of multiple cellular processes in pathogenic fungi. Here, we show that...
6.
The Significance of Lipids to Biofilm Formation in : An Emerging Perspective
Alim D, Sircaik S, Panwar S
J Fungi (Basel) . 2018 Dec; 4(4). PMID: 30567300
, the dimorphic opportunistic human fungal pathogen, is capable of forming highly drug-resistant biofilms in the human host. Formation of biofilm is a multistep and multiregulatory process involving various adaptive...
7.
Distinct roles of the 7-transmembrane receptor protein Rta3 in regulating the asymmetric distribution of phosphatidylcholine across the plasma membrane and biofilm formation in Candida albicans
Srivastava A, Sircaik S, Husain F, Thomas E, Ror S, Rastogi S, et al.
Cell Microbiol . 2017 Jul; 19(12). PMID: 28745020
Fungal pathogens such as Candida albicans exhibit several survival mechanisms to evade attack by antifungals and colonise host tissues. Rta3, a member of the Rta1-like family of lipid-translocating exporters has...
8.
The activity of RTA2, a downstream effector of the calcineurin pathway, is required during tunicamycin-induced ER stress response in Candida albicans
Thomas E, Sircaik S, Roman E, Brunel J, Johri A, Pla J, et al.
FEMS Yeast Res . 2015 Nov; 15(8). PMID: 26518191
In this study, we demonstrate a novel function of a downstream effector molecule of the calcineurin pathway, RTA2 (Resistance To Aminocholesterol), in ER stress response. The deletion of RTA2 increases...