Shabnam Khalilnezhad
Overview
Explore the profile of Shabnam Khalilnezhad including associated specialties, affiliations and a list of published articles.
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8
Citations
924
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Recent Articles
1.
Shin Park D, Kozaki T, Tiwari S, Moreira M, Khalilnezhad A, Torta F, et al.
Nature
. 2023 Nov;
623(7986):397-405.
PMID: 37914940
Microglia are specialized brain-resident macrophages that arise from primitive macrophages colonizing the embryonic brain. Microglia contribute to multiple aspects of brain development, but their precise roles in the early human...
2.
Ramirez-Valdez R, Baharom F, Khalilnezhad A, Fussell S, Hermans D, Schrager A, et al.
Cell Rep
. 2023 Jun;
42(6):112599.
PMID: 37279110
Therapeutic neoantigen cancer vaccines have limited clinical efficacy to date. Here, we identify a heterologous prime-boost vaccination strategy using a self-assembling peptide nanoparticle TLR-7/8 agonist (SNP) vaccine prime and a...
3.
Kvedaraite E, Milne P, Khalilnezhad A, Chevrier M, Sethi R, Lee H, et al.
Sci Immunol
. 2022 Dec;
7(78):eadd3330.
PMID: 36525505
Langerhans cell histiocytosis (LCH) is a potentially fatal neoplasm characterized by the aberrant differentiation of mononuclear phagocytes, driven by mitogen-activated protein kinase (MAPK) pathway activation. LCH cells may trigger destructive...
4.
Baharom F, Ramirez-Valdez R, Khalilnezhad A, Khalilnezhad S, Dillon M, Hermans D, et al.
Cell
. 2022 Oct;
185(23):4317-4332.e15.
PMID: 36302380
Therapeutic cancer vaccines are designed to increase tumor-specific T cell immunity. However, suppressive mechanisms within the tumor microenvironment (TME) may limit T cell function. Here, we assessed how the route...
5.
Mulder K, Patel A, Kong W, Piot C, Halitzki E, Dunsmore G, et al.
Immunity
. 2021 Jul;
54(8):1883-1900.e5.
PMID: 34331874
Mononuclear phagocytes (MNPs) encompass dendritic cells, monocytes, and macrophages (MoMac), which exhibit antimicrobial, homeostatic, and immunoregulatory functions. We integrated 178,651 MNPs from 13 tissues across 41 datasets to generate a...
6.
Mishra A, Lai G, Yao L, Aung T, Shental N, Rotter-Maskowitz A, et al.
Cell
. 2021 Jun;
184(13):3394-3409.e20.
PMID: 34077752
The human fetal immune system begins to develop early during gestation; however, factors responsible for fetal immune-priming remain elusive. We explored potential exposure to microbial agents in utero and their...
7.
Sharma A, Seow J, Dutertre C, Pai R, Bleriot C, Mishra A, et al.
Cell
. 2020 Sep;
183(2):377-394.e21.
PMID: 32976798
We employed scRNA sequencing to extensively characterize the cellular landscape of human liver from development to disease. Analysis of ∼212,000 cells representing human fetal, hepatocellular carcinoma (HCC), and mouse liver...
8.
Dutertre C, Becht E, Irac S, Khalilnezhad A, Narang V, Khalilnezhad S, et al.
Immunity
. 2019 Sep;
51(3):573-589.e8.
PMID: 31474513
Human mononuclear phagocytes comprise phenotypically and functionally overlapping subsets of dendritic cells (DCs) and monocytes, but the extent of their heterogeneity and distinct markers for subset identification remains elusive. By...