Sevilla D Detera-Wadleigh
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Explore the profile of Sevilla D Detera-Wadleigh including associated specialties, affiliations and a list of published articles.
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25
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882
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Recent Articles
1.
Detera-Wadleigh S, Kassem L, Besancon E, Lopes F, Akula N, Sung H, et al.
Transl Psychiatry
. 2023 Dec;
13(1):397.
PMID: 38104115
Genome-wide (GWAS) and copy number variant (CNV) association studies have reproducibly identified numerous risk alleles associated with bipolar disorder (BD), major depressive disorder (MDD), and schizophrenia (SCZ), but biological characterization...
2.
Jiang X, Detera-Wadleigh S, Akula N, Mallon B, Hou L, Xiao T, et al.
Mol Psychiatry
. 2018 Aug;
24(4):613-624.
PMID: 30135510
Biological characterization of genetic variants identified in genome-wide association studies (GWAS) remains a substantial challenge. Here we used human-induced pluripotent stem cells (iPSC) and their neural derivatives to characterize common...
3.
Ament S, Szelinger S, Glusman G, Ashworth J, Hou L, Akula N, et al.
Proc Natl Acad Sci U S A
. 2015 Mar;
112(11):3576-81.
PMID: 25730879
We sequenced the genomes of 200 individuals from 41 families multiply affected with bipolar disorder (BD) to identify contributions of rare variants to genetic risk. We initially focused on 3,087...
4.
Manchia M, Adli M, Akula N, Ardau R, Aubry J, Backlund L, et al.
PLoS One
. 2013 Jul;
8(6):e65636.
PMID: 23840348
Objective: The assessment of response to lithium maintenance treatment in bipolar disorder (BD) is complicated by variable length of treatment, unpredictable clinical course, and often inconsistent compliance. Prospective and retrospective...
5.
Ohnishi T, Yamada K, Watanabe A, Ohba H, Sakaguchi T, Honma Y, et al.
PLoS One
. 2012 Jan;
6(12):e29499.
PMID: 22242126
Mutations in the Opo gene result in eye malformation in medaka fish. The human ortholog of this gene, MRDS1/OFCC1, is a potentially causal gene for orofacial cleft, as well as...
6.
Schulze T, Alda M, Adli M, Akula N, Ardau R, Bui E, et al.
Neuropsychobiology
. 2010 May;
62(1):72-8.
PMID: 20453537
For more than half a decade, lithium has been successfully used to treat bipolar disorder. Worldwide, it is considered the first-line mood stabilizer. Apart from its proven antimanic and prophylactic...
7.
McMahon F, Akula N, Schulze T, Muglia P, Tozzi F, Detera-Wadleigh S, et al.
Nat Genet
. 2010 Jan;
42(2):128-31.
PMID: 20081856
The major mood disorders, which include bipolar disorder and major depressive disorder (MDD), are considered heritable traits, although previous genetic association studies have had limited success in robustly identifying risk...
8.
Meerabux J, Ohba H, Iwayama Y, Maekawa M, Detera-Wadleigh S, DeLisi L, et al.
J Hum Genet
. 2009 May;
54(7):386-91.
PMID: 19461657
It is suggested that chromosome 18p11 is a susceptibility region for both bipolar disorder and schizophrenia. Aiming to identify susceptibility gene(s), we investigated a family whose members have either schizophrenia...
9.
Wendland J, DeGuzman T, McMahon F, Rudnick G, Detera-Wadleigh S, Murphy D
Psychiatr Genet
. 2008 Jan;
18(1):31-9.
PMID: 18197083
Background: SERT I425V, an uncommon missense single nucleotide polymorphism producing a gain-of-function of the serotonin transporter (SERT), was originally found to segregate with a primarily obsessive-compulsive disorder (OCD) but complexly...
10.
Association study between the Down syndrome cell adhesion molecule (DSCAM) gene and bipolar disorder
Amano K, Yamada K, Iwayama Y, Detera-Wadleigh S, Hattori E, Toyota T, et al.
Psychiatr Genet
. 2008 Jan;
18(1):1-10.
PMID: 18197079
Objectives: Defects of neurodevelopmental processes are suggested to underlie the pathogenesis of bipolar disorder. Down syndrome cell adhesion molecule (DSCAM), a member of neural immunoglobulin superfamily playing a diverse role...