Seth E Karol
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Explore the profile of Seth E Karol including associated specialties, affiliations and a list of published articles.
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73
Citations
797
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Recent Articles
11.
Purvis K, Zhou Y, Karol S, Rubnitz J, Ribeiro R, Lee S, et al.
Blood
. 2024 Sep;
145(2):190-201.
PMID: 39316653
Children with ETV6::RUNX1 or high-hyperdiploid B-cell acute lymphoblastic leukemia (B-ALL) have favorable outcomes. The St. Jude (SJ) classification considers these patients low risk, regardless of their National Cancer Institute (NCI)...
12.
Mostafa A, Abramson Z, Ghbrial M, Biswas S, Chan S, Darji H, et al.
Cancer Imaging
. 2024 Aug;
24(1):115.
PMID: 39210481
Background: Patients treated for cancer have a higher incidence of focal liver lesions than the general population and there is often concern for a malignant etiology. This can result in...
13.
Stone R, Haidar C, Kornegay N, Barker P, Karol S, Wolf J, et al.
Pediatr Infect Dis J
. 2024 Aug;
PMID: 39163536
We sought to determine whether Pneumocystis jirovecii pneumonia prophylaxis with sulfamethoxazole-trimethoprim (SMX-TMP) is associated with an increased frequency of acute hemolytic anemia in patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency versus...
14.
Yoshimura S, Li Z, Gocho Y, Yang W, Crews K, Lee S, et al.
J Clin Oncol
. 2024 Aug;
42(29):3478-3490.
PMID: 39102629
Purpose: Acute lymphoblastic leukemia (ALL) can occur across all age groups, with a strikingly higher cure rate in children compared with adults. However, the pharmacological basis of age-related differences in...
15.
Lamba J, Marrero R, Wu H, Cao X, Parcha P, Karol S, et al.
JAMA Netw Open
. 2024 May;
7(5):e2411726.
PMID: 38753328
Importance: Disparities in outcomes exist between Black and White patients with acute myeloid leukemia (AML), with Black patients experiencing poorer prognosis compared with their White counterparts. Objective: To assess whether...
16.
Huang X, Li Y, Zhang J, Yan L, Zhao H, Ding L, et al.
Cancer Cell
. 2024 Apr;
42(4):552-567.e6.
PMID: 38593781
Leukemia can arise at various stages of the hematopoietic differentiation hierarchy, but the impact of developmental arrest on drug sensitivity is unclear. Applying network-based analyses to single-cell transcriptomes of human...
17.
Hashmi S, Bodea J, Patni T, Angel S, Bhakta N, Jeha S, et al.
JAMA Netw Open
. 2024 Feb;
7(2):e2355727.
PMID: 38363571
Importance: COVID-19 in pediatric patients with acute lymphoblastic leukemia or lymphoma (ALL/LLy) has not been described in detail and may affect chemotherapy administration and long-term outcomes. Objective: To describe the...
18.
Talleur A, Pui C, Karol S
Lymphatics
. 2024 Jan;
1(1):34-44.
PMID: 38269058
Cure rates now exceed 90% in many contemporary trials for children with B-cell acute lymphoblastic leukemia (ALL). However, treatment remains suboptimal and therapy is toxic for all patients. New treatment...
19.
Maillard M, Nishii R, Yang W, Hoshitsuki K, Chepyala D, Lee S, et al.
J Natl Cancer Inst
. 2024 Jan;
116(5):702-710.
PMID: 38230823
Background: Thiopurines such as mercaptopurine (MP) are widely used to treat acute lymphoblastic leukemia (ALL). Thiopurine-S-methyltransferase (TPMT) and Nudix hydrolase 15 (NUDT15) inactivate thiopurines, and no-function variants are associated with...
20.
Ceolin V, Ishimaru S, Karol S, Bautista F, Goemans B, Gueguen G, et al.
Cancers (Basel)
. 2024 Jan;
16(1).
PMID: 38201506
The prognosis of children with acute myeloid leukemia (AML) has improved incrementally over the last few decades. However, at relapse, overall survival (OS) is approximately 40-50% and is even lower...