Sergio R Filipe
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Explore the profile of Sergio R Filipe including associated specialties, affiliations and a list of published articles.
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34
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1299
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Recent Articles
1.
Lai L, Satishkumar N, Cardozo S, Hemmadi V, Marques L, Huang L, et al.
mBio
. 2024 Mar;
15(5):e0288923.
PMID: 38530033
Importance: In , high-level, broad-spectrum resistance to β-lactams such as methicillin, also referred to as methicillin resistance, is largely attributed to . This study demonstrates that strains that lack but...
2.
Lai L, Satishkumar N, Cardozo S, Hemmadi V, Marques L, Huang L, et al.
bioRxiv
. 2023 Nov;
PMID: 37961375
Infections caused by are a leading cause of mortality worldwide. infections caused by Methicillin-Resistant (MRSA) are particularly difficult to treat due to their resistance to Next Generation β-lactams (NGB) such...
3.
Veiga H, Jousselin A, Schaper S, Saraiva B, Marques L, Reed P, et al.
EMBO J
. 2023 Apr;
42(11):e112140.
PMID: 37038972
Unregulated cell cycle progression may have lethal consequences and therefore, bacteria have various mechanisms in place for the precise spatiotemporal control of cell cycle events. We have uncovered a new...
4.
Saraiva B, Krippahl L, Filipe S, Henriques R, Pinho M
Biol Imaging
. 2022 Jan;
1:e3.
PMID: 35036921
Fluorescence microscopy is a critical tool for cell biology studies on bacterial cell division and morphogenesis. Because the analysis of fluorescence microscopy images evolved beyond initial qualitative studies, numerous images...
5.
Gigante A, Olivenca F, Catalao M, Leandro P, Moniz-Pereira J, Filipe S, et al.
Viruses
. 2021 Aug;
13(7).
PMID: 34372584
Double-stranded DNA bacteriophages end their lytic cycle by disrupting the host cell envelope, which allows the release of the virion progeny. Each phage must synthesize lysis proteins that target each...
6.
Aggarwal S, Lloyd A, Yerneni S, Narciso A, Shepherd J, Roper D, et al.
Proc Natl Acad Sci U S A
. 2021 Mar;
118(14).
PMID: 33785594
Survival in the human host requires bacteria to respond to unfavorable conditions. In the important Gram-positive pathogen , cell wall biosynthesis proteins MurM and MurN are tRNA-dependent amino acyl transferases...
7.
Queda F, Covas G, Filipe S, Marques M
Pharmaceuticals (Basel)
. 2020 Nov;
13(11).
PMID: 33203094
Peptidoglycan (PGN) is a major constituent of most bacterial cell walls that is recognized as a primary target of the innate immune system. The availability of pure PGN molecules has...
8.
Queda F, Covas G, Silva T, Santos C, Bronze M, Canada F, et al.
Carbohydr Polym
. 2019 Sep;
224:115133.
PMID: 31472863
An unprecedented approach towards oligosaccharides containing N-acetylglucosamine-N-acetylmuramic (NAG-NAM) units was developed. These novel bacterial cell wall surrogates were obtained from chitosan via a top down approach involving both chemical and...
9.
Monteiro J, Covas G, Rausch D, Filipe S, Schneider T, Sahl H, et al.
Sci Rep
. 2019 Mar;
9(1):5010.
PMID: 30899062
Bacterial cells are surrounded by cell wall, whose main component is peptidoglycan (PG), a macromolecule that withstands the internal turgor of the cell. PG composition can vary considerably between species....
10.
Catalao M, Filipe S, Pimentel M
Front Microbiol
. 2019 Feb;
10:190.
PMID: 30804921
Tuberculosis (TB), which is caused by (), is one of the leading cause of death by an infectious diseases. The biosynthesis of the mycobacterial cell wall (CW) is an area...