Sergey V Kozyrev
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Explore the profile of Sergey V Kozyrev including associated specialties, affiliations and a list of published articles.
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31
Citations
962
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Recent Articles
1.
Christmas M, Dong M, Meadows J, Kozyrev S, Lindblad-Toh K
Nat Commun
. 2025 Feb;
16(1):2007.
PMID: 40011430
Mammalian genomes are biased towards GC bases at third codon positions, likely due to a GC-biased ancestral genome and the selectively neutral recombination-related process of GC-biased gene conversion. The unwanted...
2.
Bianchi M, Kozyrev S, Notarnicola A, Sandling J, Pettersson M, Leonard D, et al.
Arthritis Rheumatol
. 2024 Sep;
77(2):212-225.
PMID: 39284741
Objective: Systemic inflammatory autoimmune diseases (SIADs) such as systemic lupus erythematosus (SLE), primary Sjögren disease (pSS), and idiopathic inflammatory myopathies (myositis) are complex conditions characterized by shared circulating autoantibodies and...
3.
Nilsson M, Kozyrev S, Lindblad-Toh K, Ronnberg H, Hansson-Hamlin H
Acta Vet Scand
. 2024 Aug;
66(1):39.
PMID: 39148122
Background: The Nova Scotia Duck Tolling Retriever (NSDTR) has previously been highlighted as a breed at risk for developing immune mediated diseases and cancer. The immune response is of great...
4.
Nilsson M, Kozyrev S, Saellstrom S, Johansson S, Andersson G, Lindblad-Toh K, et al.
Sci Rep
. 2024 May;
14(1):11624.
PMID: 38773194
The Nova Scotia Duck Tolling Retriever (NSDTR) is predisposed to immune mediated rheumatic disease (IMRD), steroid-responsive meningitis-arteritis (SRMA) and certain forms of cancer. Cytokines are the main regulators of the...
5.
Schmid T, Elie J, Redlich R, Shvareva V, Rakuljic A, Ji M, et al.
Science
. 2024 Feb;
383(6690):eabn3263.
PMID: 38422184
Vocal production learning ("vocal learning") is a convergently evolved trait in vertebrates. To identify brain genomic elements associated with mammalian vocal learning, we integrated genomic, anatomical, and neurophysiological data from...
6.
Lindelof L, Rantapaa-Dahlqvist S, Lundtoft C, Sandling J, Leonard D, Sayadi A, et al.
J Autoimmun
. 2024 Jan;
143:103166.
PMID: 38219652
The complement system plays a central role in the pathogenesis of Systemic Lupus Erythematosus (SLE), but most studies have focused on the classical pathway. Ficolin-3 is the main initiator of...
7.
Roy A, Sakthikumar S, Kozyrev S, Nordin J, Pensch R, Makelainen S, et al.
Proc Natl Acad Sci U S A
. 2023 Aug;
120(33):e2300984120.
PMID: 37549291
Current knowledge of cancer genomics remains biased against noncoding mutations. To systematically search for regulatory noncoding mutations, we assessed mutations in conserved positions in the genome under the assumption that...
8.
Christmas M, Kaplow I, Genereux D, Dong M, Hughes G, Li X, et al.
Science
. 2023 Apr;
380(6643):eabn3943.
PMID: 37104599
Zoonomia is the largest comparative genomics resource for mammals produced to date. By aligning genomes for 240 species, we identify bases that, when mutated, are likely to affect fitness and...
9.
Yavuz S, Pucholt P, Sandling J, Bianchi M, Leonard D, Bolin K, et al.
Lupus Sci Med
. 2022 Nov;
9(1).
PMID: 36332927
Objective: Lupus nephritis (LN) is a common and severe manifestation of SLE. The genetic risk for nephritis and progression to end-stage renal disease (ESRD) in patients with LN remains unclear....
10.
Lundtoft C, Sjowall C, Rantapaa-Dahlqvist S, Bengtsson A, Jonsen A, Pucholt P, et al.
Arthritis Rheumatol
. 2022 Jun;
74(11):1842-1850.
PMID: 35729719
Objective: Complete genetic deficiency of the complement component C2 is a strong risk factor for monogenic systemic lupus erythematosus (SLE), but whether heterozygous C2 deficiency adds to the risk of...