Sergej Ramusovic
Overview
Explore the profile of Sergej Ramusovic including associated specialties, affiliations and a list of published articles.
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Articles
10
Citations
113
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Recent Articles
1.
Lippert J, Burghaus R, Edginton A, Frechen S, Karlsson M, Kovar A, et al.
CPT Pharmacometrics Syst Pharmacol
. 2019 Nov;
8(12):878-882.
PMID: 31671256
No abstract available.
2.
Margolskee A, Darwich A, Pepin X, Aarons L, Galetin A, Rostami-Hodjegan A, et al.
Eur J Pharm Sci
. 2016 Nov;
96:610-625.
PMID: 27816631
Orally administered drugs are subject to a number of barriers impacting bioavailability (F), causing challenges during drug and formulation development. Physiologically-based pharmacokinetic (PBPK) modelling can help during drug and formulation...
3.
Darwich A, Margolskee A, Pepin X, Aarons L, Galetin A, Rostami-Hodjegan A, et al.
Eur J Pharm Sci
. 2016 Oct;
96:626-642.
PMID: 27693299
Three Physiologically Based Pharmacokinetic software packages (GI-Sim, Simcyp® Simulator, and GastroPlus™) were evaluated as part of the Innovative Medicine Initiative Oral Biopharmaceutics Tools project (OrBiTo) during a blinded "bottom-up" anticipation...
4.
Burckhardt B, Tins J, Ramusovic S, Laer S
J Pediatr Pharmacol Ther
. 2016 Jan;
20(6):431-52.
PMID: 26766933
Objectives: Drugs that are effectively used to treat hypertension in adults (e.g., enalapril) have not been sufficiently investigated in children. Studies required for pediatric approval require special consideration regarding ethics,...
5.
Ramusovic S, Laer S, Meibohm B, Lagler F, Paul T
Arch Dis Child
. 2013 Sep;
98(12):989-93.
PMID: 24051016
Objectives: Although amiodarone is an effective treatment for severe paediatric arrhythmias, uncertainties about adverse effects such as hypotension, bradycardia and excessive serum drug concentrations persist. Therefore, the aims of this...
6.
Ramusovic S, Laeer S
J Cardiovasc Pharmacol
. 2012 Nov;
60(5):417-28.
PMID: 23143654
The renin angiotensin aldosterone system (RAAS) is a paramount target for the pharmacological treatment of cardiovascular diseases. As modeling and simulation techniques are becoming increasingly utilized in cardiovascular research, our...
7.
Burckhardt B, Ramusovic S, Tins J, Laeer S
Biomed Chromatogr
. 2012 Oct;
27(4):477-86.
PMID: 23055424
The orally active direct renin inhibitor aliskiren is approved for the treatment of essential hypertension in adults. Analytical methods utilized in clinical studies on efficacy and safety have not been...
8.
Ramusovic S, Thielking G, Laer S
Biomed Chromatogr
. 2011 Sep;
26(6):697-702.
PMID: 21953651
The angiotensin converting enzyme-inhibitor enalapril is the prodrug of enalaprilat and used in the treatment pediatric hypertension and chronic heart failure. Pharmacokinetic data are lacking to provide adequate dosing and...
9.
Ramusovic S, Laer S, Breitkreutz J
Pharm Unserer Zeit
. 2010 Oct;
39(6):454-8.
PMID: 20967934
No abstract available.
10.
Wang X, Ramusovic S, Nguyen T, Lu Z
Bioconjug Chem
. 2007 Oct;
18(6):2169-77.
PMID: 17939730
Small interfering RNA (siRNA) is a promising new therapeutic modality that can specifically silence disease-related genes. The main challenge for successful clinical development of therapeutic siRNA is the lack of...