Serena Rosignoli
Overview
Explore the profile of Serena Rosignoli including associated specialties, affiliations and a list of published articles.
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17
Citations
96
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Recent Articles
1.
Rosignoli S, Giordani S, Pacelli M, Guarguaglini G, Paiardini A
Biomolecules
. 2025 Feb;
15(2).
PMID: 40001507
PROteolysis TArgeting Chimeras (PROTACs) offer a therapeutic modality for protein target engagement, exploiting the ubiquitin-proteasome system to achieve precise degradation of a protein of interest. Recent advancements in understanding the...
2.
Tarullo M, Fernandez Rodriguez G, Iaiza A, Venezia S, Macone A, Incocciati A, et al.
ACS Pharmacol Transl Sci
. 2024 Dec;
7(12):4096-4111.
PMID: 39698280
FTO, an -methyladenosine (mA) and ,2'--dimethyladenosine (mA) RNA demethylase, is a promising target for treating acute myeloid leukemia (AML) due to the significant anticancer activity of its inhibitors in preclinical...
3.
Persello A, Tadini L, Rotasperti L, Ballabio F, Tagliani A, Torricella V, et al.
Plant Cell Rep
. 2024 Sep;
43(10):246.
PMID: 39343835
The barley mutant xan-h.chli-1 shows phenotypic features, such as reduced leaf chlorophyll content and daily transpiration rate, typical of wild barley accessions and landraces adapted to arid climatic conditions. The...
4.
Rosignoli S, Pacelli M, Manganiello F, Paiardini A
FEBS Open Bio
. 2024 Sep;
15(2):202-222.
PMID: 39313455
AlphaFold and similar groundbreaking, AI-based tools, have revolutionized the field of structural bioinformatics, with their remarkable accuracy in ab-initio protein structure prediction. This success has catalyzed the development of new...
5.
Rosignoli S, Lustrino E, Conci A, Fabrizi A, Rinaldo S, Latella M, et al.
Nucleic Acids Res
. 2024 May;
52(W1):W29-W38.
PMID: 38795068
Gene therapy of dominantly inherited genetic diseases requires either the selective disruption of the mutant allele or the editing of the specific mutation. The CRISPR-Cas system holds great potential for...
6.
Fusi R, Milner S, Rosignoli S, Bovina R, de Jesus Vieira Teixeira C, Lou H, et al.
New Phytol
. 2024 Apr;
244(1):104-115.
PMID: 38666346
Barley (Hordeum vulgare) is an important global cereal crop and a model in genetic studies. Despite advances in characterising barley genomic resources, few mutant studies have identified genes controlling root...
7.
Rosignoli S, Lustrino E, Di Silverio I, Paiardini A
Int J Mol Sci
. 2024 Feb;
25(3).
PMID: 38339009
Recent advances in protein structure prediction, driven by AlphaFold 2 and machine learning, demonstrate proficiency in static structures but encounter challenges in capturing essential dynamic features crucial for understanding biological...
8.
Barile A, Graziani C, Antonelli L, Parroni A, Fiorillo A, di Salvo M, et al.
Protein Sci
. 2024 Jan;
33(2):e4900.
PMID: 38284493
Adequate levels of pyridoxal 5'-phosphate (PLP), the catalytically active form of vitamin B , and its proper distribution in the body are essential for human health. The PLP recycling pathway...
9.
Rosignoli S, di Paola L, Paiardini A
Bioinformatics
. 2023 Nov;
39(11).
PMID: 37941462
Motivation: Protein contact networks (PCNs) represent the 3D structure of a protein using network formalism. Inter-residue contacts are described as binary adjacency matrices, which are derived from the graph representation...
10.
Li K, Tassinari A, Giuliani S, Rosignoli S, Urbany C, Tuberosa R, et al.
Front Plant Sci
. 2023 Jan;
13:1017983.
PMID: 36704171
Maize ear fasciation originates from excessive or abnormal proliferation of the ear meristem and usually manifests as flattened multiple-tipped ear and/or disordered kernel arrangement. Ear prolificacy expresses as multiple ears...