Sebastian Major
Overview
Explore the profile of Sebastian Major including associated specialties, affiliations and a list of published articles.
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49
Citations
2085
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Recent Articles
1.
Sword J, Sparks T, Debs L, Major S, Sharma S, Jensen M, et al.
Stroke
. 2025 Feb;
PMID: 40013372
Background: Decades of experimental and clinical data revealed that spreading depolarizations (SDs) play a central causal role in the development of cortical lesions after acute brain injury. However, clinical documentation...
2.
Reduced brain oxygen response to spreading depolarization predicts worse outcome in ischaemic stroke
Hecht N, Haddad D, Neumann K, Schumm L, Dengler N, Wessels L, et al.
Brain
. 2024 Nov;
PMID: 39538992
Spreading depolarization (SD) describes a propagating neuronal mass depolarization within the cerebral cortex that represents a mediator of infarct development and strongly stimulates the metabolic rate of O2 consumption. Here,...
3.
Kowoll C, Schumm L, Gieffers A, Lemale C, Major S, Dohmen C, et al.
J Cereb Blood Flow Metab
. 2024 Jun;
44(12):1550-1560.
PMID: 38902207
Spreading depolarizations (SD) contribute to lesion progression after experimental focal cerebral ischemia while such correlation has never been shown in stroke patients. In this prospective, diagnostic study, we investigate the...
4.
Preuss S, Multmeier J, Stenzel W, Major S, Ploner C, Storm C, et al.
Front Cardiovasc Med
. 2024 May;
11:1337344.
PMID: 38774664
Background: This study investigates the association between the mean arterial blood pressure (MAP), vasopressor requirement, and severity of hypoxic-ischemic encephalopathy (HIE) after cardiac arrest (CA). Methods: Between 2008 and 2017,...
5.
Dreier J, Lemale C, Horst V, Major S, Kola V, Schoknecht K, et al.
Transl Stroke Res
. 2024 Feb;
16(1):147-168.
PMID: 38396252
While subarachnoid hemorrhage is the second most common hemorrhagic stroke in epidemiologic studies, the recent DISCHARGE-1 trial has shown that in reality, three-quarters of focal brain damage after subarachnoid hemorrhage...
6.
Knab F, Koch S, Major S, Farr T, Mueller S, Euskirchen P, et al.
Stroke
. 2023 Sep;
54(11):2895-2905.
PMID: 37746704
Background: Prediction of poststroke outcome using the degree of subacute deficit or magnetic resonance imaging is well studied in humans. While mice are the most commonly used animals in preclinical...
7.
Horst V, Kola V, Lemale C, Major S, Winkler M, Hecht N, et al.
Brain Commun
. 2023 Apr;
5(2):fcad080.
PMID: 37038498
In DISCHARGE-1, a recent Phase III diagnostic trial in aneurysmal subarachnoid haemorrhage patients, spreading depolarization variables were found to be an independent real-time biomarker of delayed cerebral ischaemia. We here...
8.
Leroy S, Major S, Bublitz V, Dreier J, Koch S
Front Aging Neurosci
. 2023 Feb;
14:1076393.
PMID: 36742202
Background: Induction of general anesthesia with propofol induces radical changes in cortical network organization, leading to unconsciousness. While perioperative frontal electroencephalography (EEG) has been widely implemented in the past decades,...
9.
Meinert F, Lemale C, Major S, Helgers S, Domer P, Mencke R, et al.
Front Neurol
. 2023 Jan;
13:1091987.
PMID: 36686541
Introduction: Wyler-strip electrodes for subdural electrocorticography (ECoG) are the gold standard for continuous bed-side monitoring of pathological cortical network events, such as spreading depolarizations (SD) and electrographic seizures. Recently, SD...
10.
Kang E, Prager O, Lublinsky S, Oliveira-Ferreira A, Reiffurth C, Major S, et al.
J Cereb Blood Flow Metab
. 2022 Nov;
43(2):210-230.
PMID: 36329390
Spreading depolarization (SD) occurs in a plethora of clinical conditions including migraine aura, delayed ischemia after subarachnoid hemorrhage and malignant hemispheric stroke. It describes waves of near-breakdown of ion homeostasis,...