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Sebastian Lulf

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Recent Articles
1.
Manrique S, Sauter D, Horenkamp F, Lulf S, Yu H, Hotter D, et al.
Nat Commun . 2017 Sep; 8(1):442. PMID: 28874665
Lentiviral Nefs recruit assembly polypeptide complexes and target sorting motifs in cellular receptors to induce their internalization. While Nef-mediated CD4 downmodulation is conserved, the ability to internalize CD3 was lost...
2.
Mangino G, Famiglietti M, Capone C, Veroni C, Percario Z, Leone S, et al.
PLoS One . 2015 Jun; 10(6):e0130189. PMID: 26066624
Background: The potential role of the human immunodeficiency virus-1 (HIV-1) accessory protein Nef in the pathogenesis of neuroAIDS is still poorly understood. Nef is a molecular adapter that influences several...
3.
Lulf S, Matz J, Rouyez M, Jarviluoma A, Saksela K, Benichou S, et al.
Retrovirology . 2014 Mar; 11:24. PMID: 24620746
Background: The HIV-1 Nef protein is essential for AIDS pathogenesis by its interaction with host cell surface receptors and signaling factors. Despite its critical role as a virulence factor Nef...
4.
Jarviluoma A, Strandin T, Lulf S, Bouchet J, Makela A, Geyer M, et al.
PLoS One . 2012 Jul; 7(7):e40331. PMID: 22792285
Monoclonal and recombinant antibodies are ubiquitous tools in diagnostics, therapeutics, and biotechnology. However, their biochemical properties lack optimal robustness, their bacterial production is not easy, and possibilities to create multifunctional...
5.
Lulf S, Horenkamp F, Breuer S, Geyer M
Curr HIV Res . 2011 Nov; 9(7):543-51. PMID: 22103838
The HIV-1 Nef protein is an accessory protein of 24-27 kDa mass that mediates a multitude of effector functions in infected cells. Although not essentially required for viral replication, HIV-1...
6.
Horenkamp F, Breuer S, Schulte A, Lulf S, Weyand M, Saksela K, et al.
Traffic . 2011 Apr; 12(7):867-77. PMID: 21477083
The human immunodeficiency virus 1 (HIV-1) Nef protein is a pathogenicity factor required for effective progression to AIDS, which modulates host cell signaling pathways and T-cell receptor internalization. We have...