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Sebastian Jojoa-Cruz

Explore the profile of Sebastian Jojoa-Cruz including associated specialties, affiliations and a list of published articles. Areas
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Articles 7
Citations 244
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Recent Articles
1.
Jojoa-Cruz S, Dubin A, Lee W, Ward A
Elife . 2024 Apr; 12. PMID: 38592763
The dimeric two-pore OSCA/TMEM63 family has recently been identified as mechanically activated ion channels. Previously, based on the unique features of the structure of OSCA1.2, we postulated the potential involvement...
2.
Jojoa-Cruz S, Burendei B, Lee W, Ward A
Structure . 2023 Dec; 32(2):157-167.e5. PMID: 38103547
Members of the OSCA/TMEM63 family are mechanically activated ion channels and structures of some OSCA members have revealed the architecture of these channels and structural features that are potentially involved...
3.
Jojoa-Cruz S, Dubin A, Lee W, Ward A
bioRxiv . 2023 Oct; PMID: 37873218
The dimeric two-pore OSCA/TMEM63 family has recently been identified as mechanically activated ion channels. Previously, based on the unique features of the structure of OSCA1.2, we postulated the potential involvement...
4.
Jojoa-Cruz S, Burendei B, Lee W, Ward A
bioRxiv . 2023 Jul; PMID: 37398040
Members of the OSCA/TMEM63 are mechanically activated ion channels and structures of some OSCA members have revealed the architecture of these channels and structural features that are potentially involved in...
5.
Jojoa-Cruz S, Saotome K, Tsui C, Lee W, Sansom M, Murthy S, et al.
Nat Commun . 2022 Feb; 13(1):850. PMID: 35165281
Flycatcher1 (FLYC1), a MscS homolog, has recently been identified as a candidate mechanosensitive (MS) ion channel involved in Venus flytrap prey recognition. FLYC1 is a larger protein and its sequence...
6.
Jojoa-Cruz S, Saotome K, Murthy S, Tsui C, Sansom M, Patapoutian A, et al.
Elife . 2018 Nov; 7. PMID: 30382939
Mechanically activated ion channels underlie touch, hearing, shear-stress sensing, and response to turgor pressure. OSCA/TMEM63s are a newly-identified family of eukaryotic mechanically activated ion channels opened by membrane tension. The...
7.
Murthy S, Dubin A, Whitwam T, Jojoa-Cruz S, Cahalan S, Mousavi S, et al.
Elife . 2018 Nov; 7. PMID: 30382938
Mechanically activated (MA) ion channels convert physical forces into electrical signals, and are essential for eukaryotic physiology. Despite their importance, few bona-fide MA channels have been described in plants and...