Sebastian Igelmann
Overview
Explore the profile of Sebastian Igelmann including associated specialties, affiliations and a list of published articles.
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Articles
17
Citations
613
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0
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Recent Articles
1.
Doglioni G, Fernandez-Garcia J, Igelmann S, Altea-Manzano P, Blomme A, La Rovere R, et al.
Nature
. 2025 Jan;
638(8049):244-250.
PMID: 39743589
Lung metastases occur in up to 54% of patients with metastatic tumours. Contributing factors to this high frequency include the physical properties of the pulmonary system and a less oxidative...
2.
Laliberte C, Bosse B, Bourdeau V, Prieto L, Perron-Deshaies G, Vuong-Robillard N, et al.
Biomedicines
. 2024 May;
12(5).
PMID: 38791051
Senescent cells, which accumulate with age, exhibit a pro-inflammatory senescence-associated secretory phenotype (SASP) that includes the secretion of cytokines, lipids, and extracellular vesicles (EVs). Here, we established an in vitro...
3.
Ali M, Wahba H, Igelmann S, Cyr N, Ferbeyre G, Omichinski J
Autophagy
. 2024 May;
20(9):1948-1967.
PMID: 38726830
The Atg8-family proteins (MAP1LC3/LC3A, LC3B, LC3C, GABARAP, GABARAPL1 and GABARAPL2) play a pivotal role in macroautophagy/autophagy through their ability to help form autophagosomes. Although autophagosomes form in the cytoplasm, nuclear...
4.
Urrutia A, Mesa-Ciller C, Guajardo-Grence A, Alkan H, Soro-Arnaiz I, Vandekeere A, et al.
Cell Rep
. 2024 Apr;
43(4):114103.
PMID: 38607920
Hypoxia-inducible factor-1α (HIF1α) attenuates mitochondrial activity while promoting glycolysis. However, lower glycolysis is compromised in human clear cell renal cell carcinomas, in which HIF1α acts as a tumor suppressor by...
5.
Planque M, Igelmann S, Ferreira Campos A, Fendt S
Curr Opin Chem Biol
. 2023 Jul;
76:102362.
PMID: 37413787
Mass spectrometry imaging (MSI) is an emerging technology in cancer metabolomics. Desorption electrospray ionization (DESI) and matrix-assisted laser desorption ionization (MALDI) MSI are complementary techniques to identify hundreds of metabolites...
6.
Parisotto M, Vuong-Robillard N, Kalegari P, Meharwade T, Joumier L, Igelmann S, et al.
Cancers (Basel)
. 2022 Nov;
14(22).
PMID: 36428689
Pancreatic cancer (pancreatic ductal adenocarcinoma: PDAC) is one of the most aggressive neoplastic diseases. Metformin use has been associated with reduced pancreatic cancer incidence and better survival in diabetics. Metformin...
7.
Lussier-Price M, Wahba H, Mascle X, Cappadocia L, Bourdeau V, Gagnon C, et al.
Nucleic Acids Res
. 2022 Jul;
50(14):8331-8348.
PMID: 35871297
SUMO proteins are important regulators of many key cellular functions in part through their ability to form interactions with other proteins containing SUMO interacting motifs (SIMs). One characteristic feature of...
8.
Igelmann S, Lessard F, Ferbeyre G
Cancers (Basel)
. 2022 Apr;
14(7).
PMID: 35406602
The cancer state is thought to be maintained by genetic and epigenetic changes that drive a cancer-promoting gene expression program. However, recent results show that cellular states can be also...
9.
Del Toro N, Lessard F, Bouchard J, Mobasheri N, Guillon J, Igelmann S, et al.
Biol Open
. 2021 Oct;
10(12).
PMID: 34676390
The origin and evolution of cancer cells is considered to be mainly fueled by DNA mutations. Although translation errors could also expand the cellular proteome, their role in cancer biology...
10.
Igelmann S, Lessard F, Uchenunu O, Bouchard J, Fernandez-Ruiz A, Rowell M, et al.
Mol Cell
. 2021 Sep;
81(18):3848-3865.e19.
PMID: 34547241
Metabolic rewiring and redox balance play pivotal roles in cancer. Cellular senescence is a barrier for tumorigenesis circumvented in cancer cells by poorly understood mechanisms. We report a multi-enzymatic complex...