Sebastian Exner
Overview
Explore the profile of Sebastian Exner including associated specialties, affiliations and a list of published articles.
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Articles
9
Citations
97
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0
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Recent Articles
1.
Manikowski D, Steffes G, Froese J, Exner S, Ehring K, Gude F, et al.
Front Mol Biosci
. 2023 Mar;
10:1130064.
PMID: 36911531
Morphogens determine cellular differentiation in many developing tissues in a concentration dependent manner. As a central model for gradient formation during animal development, Hedgehog (Hh) morphogens spread away from their...
2.
Gruen A, Exner S, Kuhl J, von Stackelberg A, Budach V, Stromberger C, et al.
Strahlenther Onkol
. 2021 Jul;
198(1):33-38.
PMID: 34282476
Background: Total body irradiation (TBI) is an established part of conditioning regimens prior to stem cell transplantation in childhood leukemia but is associated with long-term toxicity. We retrospectively analyzed survival,...
3.
Jakobs P, Schulz P, Schurmann S, Niland S, Exner S, Rebollido-Rios R, et al.
J Cell Sci
. 2017 Aug;
130(19):3261-3271.
PMID: 28778988
Proteolytic processing of cell-surface-bound ligands, called shedding, is a fundamental system to control cell-cell signaling. Yet, our understanding of how shedding is regulated is still incomplete. One way to increase...
4.
Kaul D, Florange J, Badakhshi H, Grun A, Ghadjar P, Exner S, et al.
Radiat Oncol
. 2016 May;
11:70.
PMID: 27209069
Introduction: Hyperfractionated (HFRT) or accelerated hyperfractionated radiotherapy (AHFRT) have been discussed as a potential treatment for glioblastoma based on a hypothesized reduction of late radiation injury and prevention of repopulation....
5.
Ortmann C, Pickhinke U, Exner S, Ohlig S, Lawrence R, Jboor H, et al.
J Cell Sci
. 2015 Dec;
128(23):4462.
PMID: 26627558
No abstract available.
6.
Ortmann C, Pickhinke U, Exner S, Ohlig S, Lawrence R, Jboor H, et al.
J Cell Sci
. 2015 May;
128(12):2374-85.
PMID: 25967551
All Hedgehog morphogens are released from producing cells, despite being synthesized as N- and C-terminally lipidated molecules, a modification that firmly tethers them to the cell membrane. We have previously...
7.
Bandari S, Exner S, Ortmann C, Bachvarova V, Vortkamp A, Grobe K
Curr Protein Pept Sci
. 2015 Feb;
16(1):66-76.
PMID: 25692848
Morphogens exert their effects over long distances, typically by spreading from cell to cell to activate signal transduction in surrounding tissues in concentration-dependent manner. One example of a morphogen is...
8.
Jakobs P, Exner S, Schurmann S, Pickhinke U, Bandari S, Ortmann C, et al.
J Cell Sci
. 2014 Feb;
127(Pt 8):1726-37.
PMID: 24522195
All morphogens of the Hedgehog (Hh) family are synthesized as dual-lipidated proteins, which results in their firm attachment to the surface of the cell in which they were produced. Thus,...
9.
Grullich C, Richter M, Exner S, Finke J
Eur J Haematol
. 2003 Aug;
71(3):184-8.
PMID: 12930319
The Fas ligand (FasL) pathway is one of the two major effector mechanisms of T-cell-mediated cell death. FasL expression by extralymphatic tissues is thought to maintain a status of immunity....