Sebastian E Koschade
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Explore the profile of Sebastian E Koschade including associated specialties, affiliations and a list of published articles.
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20
Citations
178
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Recent Articles
11.
Koschade S, Klann K, Shaid S, Vick B, Stratmann J, Tholken M, et al.
Leukemia
. 2022 Aug;
36(10):2396-2407.
PMID: 35999260
Internal tandem duplications (ITD) in the receptor tyrosine kinase FLT3 occur in 25 % of acute myeloid leukemia (AML) patients, drive leukemia progression and confer a poor prognosis. Primary resistance...
12.
Koschade S, Stratmann J, Finkelmeier F, Wagner S, Chromik J, Steffen B, et al.
Ann Hematol
. 2022 May;
101(8):1703-1710.
PMID: 35595925
The optimal follow-up care for relapse detection in acute myeloid leukemia (AML) patients in first remission after consolidation therapy with intensive chemotherapy is not established. In this retrospective study, we...
13.
Baker F, Polat I, Abou-El-Ardat K, Alshamleh I, Thoelken M, Hymon D, et al.
Cancers (Basel)
. 2021 Dec;
13(23).
PMID: 34885250
Autophagy is an important survival mechanism that allows recycling of nutrients and removal of damaged organelles and has been shown to contribute to the proliferation of acute myeloid leukemia (AML)...
14.
Koschade S, Stratmann J, Miesbach W, Steffen B, Serve H, Finkelmeier F, et al.
Eur J Haematol
. 2021 Oct;
108(2):125-132.
PMID: 34714547
Objectives And Methods: Intracranial hemorrhage (ICH) in acute myeloid leukemia (AML) patients is a major concern due to the increased risk of mortality. Few studies have examined ICH specifically in...
15.
Weber S, Koschade S, Hoffmann C, Dubash T, Giessler K, Dieter S, et al.
BMC Cancer
. 2019 Dec;
19(1):1181.
PMID: 31796022
Background: While colorectal cancer (CRC) patients with localized disease have a favorable prognosis, the five-year-survival rate in patients with distant spread is still below 15%. Hence, a detailed understanding of...
16.
Koschade S, Brandts C
J Mol Biol
. 2019 Jul;
432(1):261-282.
PMID: 31260695
The hierarchical organization of the hematopoietic system requires hematopoietic stem cells (HSCs) capable of self-renewal and multilineage differentiation to produce all cellular lineages of the blood. Novel techniques of purification...
17.
Koschade S, Koch M, Braunger B, Tamm E
Exp Eye Res
. 2019 Jun;
186:107710.
PMID: 31254512
Quantifying the number of axons in the optic nerve is of interest in many research questions. Here, we show that a stereological method allows simple, efficient, precise and unbiased determination...
18.
Chaikuad A, Koschade S, Stolz A, Zivkovic K, Pohl C, Shaid S, et al.
Biochem J
. 2019 Feb;
476(5):875-887.
PMID: 30782972
Autophagy is essential for cellular homeostasis and when deregulated this survival mechanism has been associated with disease development. Inhibition of autophagy initiation by inhibiting the kinase ULK1 (Unc-51-like autophagy activating...
19.
Nguyen T, Shaid S, Vakhrusheva O, Koschade S, Klann K, Tholken M, et al.
Blood
. 2018 Dec;
133(2):168-179.
PMID: 30498063
Autophagy maintains hematopoietic stem cell integrity and prevents malignant transformation. In addition to bulk degradation, selective autophagy serves as an intracellular quality control mechanism and requires autophagy receptors, such as...
20.
Braunger B, Ademoglu B, Koschade S, Fuchshofer R, Gabelt B, Kiland J, et al.
Invest Ophthalmol Vis Sci
. 2014 Oct;
55(11):7499-507.
PMID: 25324280
Purpose: To identify stem cells in the chamber angle of the monkey eye by detection of 5-bromo-2'-deoxyuridine (BrdU) long-term retention. Methods: Four cynomolgus monkeys were treated with BrdU via subcutaneous...