Sean E OLeary
Overview
Explore the profile of Sean E OLeary including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
28
Citations
886
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Hong H, Zhang A, Conn A, Blaha G, OLeary S
Sci Adv
. 2024 Oct;
10(40):eadm9801.
PMID: 39356761
How eukaryotic ribosomes traverse messenger RNA (mRNA) leader sequences to search for protein-synthesis start sites remains one of the most mysterious aspects of translation and its regulation. While the search...
2.
Wang F, Holmes M, Hong H, Thaprawat P, Kannan G, Huynh M, et al.
Nat Commun
. 2024 May;
15(1):4385.
PMID: 38782906
The parasite Toxoplasma gondii persists in its hosts by converting from replicating tachyzoites to latent bradyzoites housed in tissue cysts. The molecular mechanisms that mediate T. gondii differentiation remain poorly...
3.
Wang F, Holmes M, Hong H, Thaprawat P, Kannan G, Huynh M, et al.
bioRxiv
. 2023 Nov;
PMID: 37961607
The parasite persists in its hosts by converting from replicating tachyzoites to latent bradyzoites housed in tissue cysts. The molecular mechanisms that mediate differentiation remain poorly understood. Through a mutagenesis...
4.
Cetin B, OLeary S
Nucleic Acids Res
. 2022 Jul;
50(14):8240-8261.
PMID: 35871304
mRNA 5' cap recognition by eIF4F is a key element of eukaryotic translational control. Kinetic differences in eIF4F-mRNA interactions have long been proposed to mediate translation-efficiency differences between mRNAs, and...
5.
Hong H, Guevara M, Lin E, OLeary S
bioRxiv
. 2021 Jun;
PMID: 34075378
Coronaviruses initiate translation through recognition of the viral RNA 5' m GpppA cap by translation factor eIF4F. eIF4F is a heterotrimeric protein complex with cap-binding, RNA-binding, and RNA helicase activities....
6.
Ren W, Fan H, Grimm S, Kim J, Li L, Guo Y, et al.
Nat Commun
. 2021 May;
12(1):2490.
PMID: 33941775
DNA methylation and trimethylated histone H4 Lysine 20 (H4K20me3) constitute two important heterochromatin-enriched marks that frequently cooperate in silencing repetitive elements of the mammalian genome. However, it remains elusive how...
7.
Cetin B, Song G, OLeary S
J Am Chem Soc
. 2020 Dec;
142(51):21249-21253.
PMID: 33315378
Dynamic RNA-protein interactions underpin numerous molecular control mechanisms in biology. However, relatively little is known about the kinetic landscape of protein interactions with full-length RNAs. The extent to which interaction...
8.
Wang B, Thurmond S, Zhou K, Sanchez-Aparicio M, Fang J, Lu J, et al.
Nat Struct Mol Biol
. 2020 Aug;
27(10):875-885.
PMID: 32778820
Suppressing cellular signal transducers of transcription 2 (STAT2) is a common strategy that viruses use to establish infections, yet the detailed mechanism remains elusive, owing to a lack of structural...
9.
Ren W, Fan H, Grimm S, Guo Y, Kim J, Yin J, et al.
Proc Natl Acad Sci U S A
. 2020 Jul;
117(31):18439-18447.
PMID: 32675241
In mammals, repressive histone modifications such as trimethylation of histone H3 Lys9 (H3K9me3), frequently coexist with DNA methylation, producing a more stable and silenced chromatin state. However, it remains elusive...
10.
Martinez P, Dixit R, Balkunde R, Zhang A, OLeary S, Brakke K, et al.
J Cell Biol
. 2020 Jun;
219(8).
PMID: 32568386
The microtubule cytoskeleton serves as a dynamic structural framework for mitosis in eukaryotic cells. TANGLED1 (TAN1) is a microtubule-binding protein that localizes to the division site and mitotic microtubules and...