Sean A Burnap
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Explore the profile of Sean A Burnap including associated specialties, affiliations and a list of published articles.
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21
Citations
262
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Recent Articles
1.
Defining proteoform-specific interactions for drug targeting in a native cell signalling environment
Lutomski C, Bennett J, El-Baba T, Wu D, Hinkle J, Burnap S, et al.
Nat Chem
. 2025 Jan;
17(2):204-214.
PMID: 39806141
Understanding the dynamics of membrane protein-ligand interactions within a native lipid bilayer is a major goal for drug discovery. Typically, cell-based assays are used, however, they are often blind to...
2.
Burnap S, Calvaresi V, Cabrera G, Pousa S, Limonta M, Ramos Y, et al.
Glycobiology
. 2025 Jan;
35(3).
PMID: 39799562
Abdala is a COVID-19 vaccine produced in Pichia pastoris and is based on the receptor-binding domain (RBD) of the SARS-CoV-2 spike. Abdala is currently approved for use in multiple countries...
3.
Asor R, Olerinyova A, Burnap S, Kushwah M, Soltermann F, Rudden L, et al.
Proc Natl Acad Sci U S A
. 2024 Sep;
121(40):e2403260121.
PMID: 39298475
Cellular processes are controlled by the thermodynamics of the underlying biomolecular interactions. Frequently, structural investigations use one monomeric binding partner, while ensemble measurements of binding affinities generally yield one affinity...
4.
Liu Y, Bineva-Todd G, Meek R, Mazo L, Piniello B, Moroz O, et al.
J Am Chem Soc
. 2024 Sep;
146(39):26707-26718.
PMID: 39287665
Correct elaboration of N-linked glycans in the secretory pathway of human cells is essential in physiology. Early N-glycan biosynthesis follows an assembly line principle before undergoing crucial elaboration points that...
5.
Deimel L, Moynie L, Sun G, Lewis V, Turner A, Buchanan C, et al.
Nat Commun
. 2024 Sep;
15(1):7955.
PMID: 39261497
No abstract available.
6.
Deimel L, Moynie L, Sun G, Lewis V, Turner A, Buchanan C, et al.
Nat Commun
. 2024 Aug;
15(1):6851.
PMID: 39127707
Many archetypal and emerging classes of small-molecule therapeutics form covalent protein adducts. In vivo, both the resulting conjugates and their off-target side-conjugates have the potential to elicit antibodies, with implications...
7.
Burnap S, Ortega-Prieto A, Jimenez-Guardeno J, Ali H, Takov K, Fish M, et al.
Mol Cell Proteomics
. 2023 Jun;
22(8):100600.
PMID: 37343697
High-density lipoprotein (HDL) levels are reduced in patients with coronavirus disease 2019 (COVID-19), and the extent of this reduction is associated with poor clinical outcomes. While lipoproteins are known to...
8.
El-Baba T, Lutomski C, Burnap S, Bolla J, Baker L, Baldwin A, et al.
J Am Chem Soc
. 2023 Mar;
145(14):8021-8032.
PMID: 37000485
Interactions between the SARS-CoV-2 Spike protein and ACE2 are one of the most scrutinized reactions of our time. Yet, questions remain as to the impact of glycans on mediating ACE2...
9.
Duregotti E, Reumiller C, Mayr U, Hasman M, Schmidt L, Burnap S, et al.
Nat Commun
. 2022 Nov;
13(1):7269.
PMID: 36433953
While the endocrine function of white adipose tissue has been extensively explored, comparatively little is known about the secretory activity of less-investigated fat depots. Here, we use proteomics to compare...
10.
Burnap S, Struwe W
Chem Commun (Camb)
. 2022 Nov;
58(93):12939-12942.
PMID: 36317551
Here we show using mass photometry how proline substitutions, commonly used for SARS-CoV-2 spike stabilisation in vaccine design, directly affects ACE2 receptor interactions dynamics of open and closed states. Conformational...