Scott Semple
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Explore the profile of Scott Semple including associated specialties, affiliations and a list of published articles.
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36
Citations
781
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Recent Articles
1.
Nash J, Debono S, Whittington B, Kaczynski J, Clark T, Macnaught G, et al.
Eur J Nucl Med Mol Imaging
. 2024 Mar;
51(8):2260-2270.
PMID: 38456972
Introduction: Non-invasive detection of pathological changes in thoracic aortic disease remains an unmet clinical need particularly for patients with congenital heart disease. Positron emission tomography combined with magnetic resonance imaging...
2.
Griffiths K, Smart S, Barker G, Deakin B, Lawrie S, Lewis S, et al.
Schizophr Res
. 2023 Sep;
260:152-159.
PMID: 37657282
Dysfunction of glutamate neurotransmission has been implicated in the pathophysiology of schizophrenia and may be particularly relevant in severe, treatment-resistant symptoms. The underlying mechanism may involve hypofunction of the NMDA...
3.
Joshi S, Singh T, Kershaw L, Gibb F, Dweck M, Williams M, et al.
Diabet Med
. 2023 Apr;
40(10):e15111.
PMID: 37035965
Aims: To investigate whether manganese-enhanced magnetic resonance imaging can assess functional pancreatic beta-cell mass in people with type 1 diabetes mellitus. Methods: In a prospective case-control study, 20 people with...
4.
Naredo-Gonzalez G, Upreti R, Jansen M, Semple S, Sutcliffe O, Marshall I, et al.
Sci Rep
. 2022 Sep;
12(1):16268.
PMID: 36175417
11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) amplifies tissue glucocorticoid levels and is a pharmaceutical target in diabetes and cognitive decline. Clinical translation of inhibitors is hampered by lack of in vivo...
5.
Griffiths K, Egerton A, Millgate E, Anton A, Barker G, Deakin B, et al.
Schizophrenia (Heidelb)
. 2022 Jul;
8(1):60.
PMID: 35853881
Impaired cognition is associated with lower quality of life and poor outcomes in schizophrenia. Brain glutamate may contribute to both clinical outcomes and cognition, but these relationships are not well-understood....
6.
Minderhoud S, Fletcher A, Macnaught G, Cadet S, Korteland S, Kardys I, et al.
Eur Heart J Cardiovasc Imaging
. 2022 Jun;
23(12):1698-1707.
PMID: 35666823
Aims: The influence haemodynamics have on vessel wall pathobiology in aortic disease is incomplete. This aim of this study was to develop a repeatable method for assessing the relationship between...
7.
Wheater E, Galdi P, McCartney D, Blesa M, Sullivan G, Stoye D, et al.
Brain Commun
. 2022 Apr;
4(2):fcac056.
PMID: 35402911
Preterm birth is associated with dysconnectivity of structural brain networks and is a leading cause of neurocognitive impairment in childhood. Variation in DNA methylation is associated with early exposure to...
8.
Bularga A, Hung J, Daghem M, Stewart S, Taggart C, Wereski R, et al.
Circulation
. 2022 Mar;
145(16):1188-1200.
PMID: 35341327
Background: Type 2 myocardial infarction is caused by myocardial oxygen supply-demand imbalance, and its diagnosis is increasingly common with the advent of high-sensitivity cardiac troponin assays. Although this diagnosis is...
9.
Brennan P, MacMillan M, Manship T, Moroni F, Glover A, Graham C, et al.
BMJ Open
. 2021 Nov;
11(11):e053190.
PMID: 34750149
Introduction: Liver cirrhosis is a growing global healthcare challenge. Cirrhosis is characterised by severe liver fibrosis, organ dysfunction and complications related to portal hypertension. There are no licensed antifibrotic or...
10.
Warner P, Whitaker L, Parker R, Weir C, Douglas A, Holm Hansen C, et al.
EBioMedicine
. 2021 Jul;
69:103434.
PMID: 34218053
Background: The symptom of heavy menstrual bleeding (HMB) diminishes quality-of-life for many mid-age women and imposes substantial societal burden. We investigated our hypothesis that HMB reflects impaired endometrial vasoconstriction due...