Scott K Durum
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Explore the profile of Scott K Durum including associated specialties, affiliations and a list of published articles.
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Recent Articles
11.
Brice D, Murray G, Wilson H, Porter R, Berry S, Durum S, et al.
Biology (Basel)
. 2022 Mar;
11(3).
PMID: 35336801
A treatment with direct healing effects on the gastrointestinal epithelial barrier is desirable for inflammatory bowel disease (IBD). Interleukin-27 (IL-27) is an immunoregulatory cytokine, and oral delivery is an effective...
12.
Serafini N, Jarade A, Surace L, Goncalves P, Sismeiro O, Varet H, et al.
Science
. 2022 Feb;
375(6583):859-863.
PMID: 35201883
Group 3 innate lymphoid cells (ILC3s) are innate immune effectors that contribute to host defense. Whether ILC3 functions are stably modified after pathogen encounter is unknown. Here, we assess the...
13.
Rodrigues G, Cramer S, Winer H, Hixon J, Li W, Yunes J, et al.
Adv Biol Regul
. 2021 Feb;
80:100788.
PMID: 33578108
The IL-7 pathway is required for normal T cell development and survival. In recent years the pathway has been shown to be a major driver of acute lymphoblastic leukemia (ALL),...
14.
Aggor F, Break T, Trevejo-Nunez G, Whibley N, Coleman B, Bailey R, et al.
Sci Immunol
. 2020 Jun;
5(48).
PMID: 32503875
Oropharyngeal candidiasis (OPC; thrush) is an opportunistic infection caused by the commensal fungus Interleukin-17 (IL-17) and IL-22 are cytokines produced by type 17 lymphocytes. Both cytokines mediate antifungal immunity yet...
15.
Barata J, Durum S, Seddon B
Nat Immunol
. 2019 Nov;
20(12):1584-1593.
PMID: 31745336
The cytokine IL-7 and its receptor, IL-7R, are critical for T cell and, in the mouse, B cell development, as well as differentiation and survival of naive T cells, and...
16.
Pinto I, Duque M, Goncalves J, Akkapeddi P, Oliveira M, Cabrita R, et al.
Oncogene
. 2019 Oct;
39(5):975-986.
PMID: 31586130
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological malignancy with a dismal prognosis in patients with resistant or relapsed disease. Although NOTCH is a known driver in T-ALL, its...
17.
Chen L, Strohmeier V, He Z, Deshpande M, Catalan-Dibene J, Durum S, et al.
Nat Commun
. 2019 Oct;
10(1):4517.
PMID: 31586069
Neonatal inflammatory diseases are associated with severe morbidity, but the inflammatory factors underlying them and their potential effector mechanisms are poorly defined. Here we show that necrotizing enterocolitis in neonate...
18.
Hixon J, Andrews C, Kashi L, Kohnhorst C, Senkevitch E, Czarra K, et al.
Leukemia
. 2019 Aug;
34(1):35-49.
PMID: 31439943
Pediatric T cell acute lymphoblastic leukemia (T-ALL) cells frequently contain mutations in the interleukin-7 (IL-7) receptor pathway or respond to IL-7 itself. To target the IL-7 receptor on T-ALL cells,...
19.
Starkey M, Plank M, Casolari P, Papi A, Pavlidis S, Guo Y, et al.
Eur Respir J
. 2019 Jun;
54(1).
PMID: 31196943
Chronic obstructive pulmonary disease (COPD) is the third leading cause of morbidity and death globally. The lack of effective treatments results from an incomplete understanding of the underlying mechanisms driving...
20.
Marchitto M, Dillen C, Liu H, Miller R, Archer N, Ortines R, et al.
Proc Natl Acad Sci U S A
. 2019 May;
116(22):10917-10926.
PMID: 31088972
T cell cytokines contribute to immunity against , but the predominant T cell subsets involved are unclear. In an skin infection mouse model, we found that the IL-17 response was...