Scott Gehler
Overview
Explore the profile of Scott Gehler including associated specialties, affiliations and a list of published articles.
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Articles
9
Citations
324
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0
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Recent Articles
1.
Jones A, Gehler S
Integr Cancer Ther
. 2020 Jun;
19:1534735420918945.
PMID: 32493139
Naturally occurring flavonoids, such as acacetin and pinostrobin, disrupt a wide range of processes during tumor progression, such as cell proliferation, apoptosis, and angiogenesis. Although the antiproliferative and antiapoptotic effects...
2.
Gehler S, Compere F, Miller A
Int J Breast Cancer
. 2017 Feb;
2017:9619734.
PMID: 28182100
Interactions between integrin-mediated adhesions and the extracellular matrix (ECM) are important regulators of cell migration and spreading. However, mechanisms by which extracellular ligands regulate cell migration and spreading in response...
3.
Gehler S, Ponik S, Riching K, Keely P
Crit Rev Eukaryot Gene Expr
. 2013 Apr;
23(2):139-57.
PMID: 23582036
Cell transformation and tumor progression involve a common set of acquired capabilities, including increased proliferation, failure of cell death, self-sufficiency in growth, angiogenesis, and tumor cell invasion and metastasis. The...
4.
Gehler S, Baldassarre M, Lad Y, Leight J, Wozniak M, Riching K, et al.
Mol Biol Cell
. 2009 May;
20(14):3224-38.
PMID: 19458194
The physical properties of the extracellular matrix (ECM) regulate the behavior of several cell types; yet, mechanisms by which cells recognize and respond to changes in these properties are not...
5.
Keely P, Conklin M, Gehler S, Ponik S, Provenzano P
Methods Enzymol
. 2007 Aug;
426:27-45.
PMID: 17697878
There has been much recent interest in working with cells cultured in three-dimensional (3D) matrices to better model the properties of the extracellular matrix environment found in vivo. However, working...
6.
Chen T, Gehler S, Shaw A, Bamburg J, Letourneau P
J Neurobiol
. 2005 Oct;
66(2):103-14.
PMID: 16215999
Rho family GTPases have important roles in mediating the effects of guidance cues and growth factors on the motility of neuronal growth cones. We previously showed that the neurotrophin BDNF...
7.
Fass J, Gehler S, Sarmiere P, Letourneau P, Bamburg J
Anat Sci Int
. 2005 Jan;
79(4):173-83.
PMID: 15633455
The regulation of filopodial dynamics by neurotrophins and other guidance cues plays an integral role in growth cone pathfinding. Filopodia are F-actin-based structures that explore the local environment, generate forces...
8.
Gehler S, Shaw A, Sarmiere P, Bamburg J, Letourneau P
J Neurosci
. 2004 Nov;
24(47):10741-9.
PMID: 15564592
The molecular mechanisms by which neurotrophins regulate growth cone motility are not well understood. This study investigated the signaling involved in transducing BDNF-induced increases of filopodial dynamics. Our results indicate...
9.
Gehler S, Gallo G, Veien E, Letourneau P
J Neurosci
. 2004 May;
24(18):4363-72.
PMID: 15128850
The mechanisms by which neurotrophins regulate growth cone motility are unclear. We investigated the role of the p75 neurotrophin receptor (p75NTR) in mediating neurotrophin-induced increases in filopodial length. Our data...