Scott G Denham
Overview
Explore the profile of Scott G Denham including associated specialties, affiliations and a list of published articles.
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9
Citations
35
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Recent Articles
1.
Lahti-Pulkkinen M, Raikkonen K, Basiukajc A, Lee P, Denham S, Simpson J, et al.
J Steroid Biochem Mol Biol
. 2025 Feb;
248:106691.
PMID: 39921041
Steroids, including mineralocorticoids, glucocorticoids, and sex hormones play a critical role in pregnancy. Liquid chromatography tandem mass spectrometry (LC-MS/MS) analysis offers an opportunity to conduct simultaneous multiplex steroid analysis within...
2.
Malbon A, Malbon A, Czopek A, Beekman A, Beekman A, Goddard Z, et al.
Biosci Rep
. 2025 Jan;
45(2):157-170.
PMID: 39869501
Approximately one in every 800 children is born with the severe aneuploid condition of Down syndrome (DS), a trisomy of chromosome 21. Low blood pressure (hypotension) is a common condition...
3.
Denham S, Simpson J, Diez F, Lee P, Kyle C, Morgan R, et al.
MethodsX
. 2024 Jul;
12:102728.
PMID: 38948242
Chromatography combined with mass spectrometry is a gold standard technique for steroid measurement, however the type of sample preparation, the dynamic range and reliability of the calibration curve, the chromatographic...
4.
Devine K, Russell C, Blanco G, Walker B, Homer N, Denham S, et al.
Clin Endocrinol (Oxf)
. 2024 Jan;
100(4):317-327.
PMID: 38229583
Objective: Endocrine systems are disrupted in acute illness, and symptoms reported following coronavirus disease 2019 (COVID-19) are similar to those found with clinical hormone deficiencies. We hypothesised that people with...
5.
Gregory S, Denham S, Lee P, Simpson J, Homer N
Metabolites
. 2023 Feb;
13(2).
PMID: 36837884
A number of steroids, including glucocorticoids and sex hormones, have been associated with neurodegenerative and cardiovascular conditions common in aging populations. The application of liquid chromatography tandem mass spectrometry (LC-MS/MS)...
6.
Ostinelli G, Laforest S, Denham S, Gauthier M, Drolet-Labelle V, Scott E, et al.
J Clin Endocrinol Metab
. 2022 May;
107(8):e3330-e3342.
PMID: 35511873
Context: Body fat distribution is a risk factor for obesity-associated comorbidities, and adipose tissue dysfunction plays a role in this association. In humans, there is a sex difference in body...
7.
Carter R, Gibbins M, Barrios-Llerena M, Wilkie S, Freddolino P, Libiad M, et al.
Cell Rep
. 2021 Nov;
37(6):109958.
PMID: 34758301
Impaired hepatic glucose and lipid metabolism are hallmarks of type 2 diabetes. Increased sulfide production or sulfide donor compounds may beneficially regulate hepatic metabolism. Disposal of sulfide through the sulfide...
8.
Hurst E, Mellanby R, Handel I, Griffith D, Rossi A, Walsh T, et al.
BMJ Open
. 2021 Oct;
11(10):e055435.
PMID: 34686560
Objectives: The steroid hormone vitamin D has roles in immunomodulation and bone health. Insufficiency is associated with susceptibility to respiratory infections. We report 25-hydroxy vitamin D (25(OH)D) measurements in hospitalised...
9.
Bell R, Villalobos E, Nixon M, Miguelez-Crespo A, Murphy L, Fawkes A, et al.
Mol Metab
. 2021 Mar;
48:101225.
PMID: 33785425
Objective: Carbonyl reductase 1 (Cbr1), a recently discovered contributor to tissue glucocorticoid metabolism converting corticosterone to 20β-dihydrocorticosterone (20β-DHB), is upregulated in adipose tissue of obese humans and mice and may...
10.
Faqehi A, Denham S, Naredo G, Cobice D, Khan S, Simpson J, et al.
J Chromatogr A
. 2021 Feb;
1640:461933.
PMID: 33588275
Liquid Chromatography tandem mass spectrometry (LC-MS/MS) is the gold-standard approach for androgen analysis in biological fluids, superseding immunoassays in selectivity, particularly at low concentrations. While LC-MS/MS is established for analysis...