Savvas Christoforidis
Overview
Explore the profile of Savvas Christoforidis including associated specialties, affiliations and a list of published articles.
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26
Citations
989
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Recent Articles
1.
Siokatas C, Lampropoulou A, Smina A, Soupsana K, Kontostathi M, Karra A, et al.
ACS Pharmacol Transl Sci
. 2024 Dec;
7(12):3955-3968.
PMID: 39698270
Although small-molecule inhibitors with moderate efficacy targeting MYC have been previously described, to this point, research efforts have failed to bring a suitable small-molecule MYC inhibitor to the clinic. Herein,...
2.
Schuhmacher J, Tom Dieck S, Christoforidis S, Landerer C, Davila Gallesio J, Hersemann L, et al.
Mol Cell
. 2023 Jun;
83(11):1839-1855.e13.
PMID: 37267905
Localized translation is vital to polarized cells and requires precise and robust distribution of different mRNAs and ribosomes across the cell. However, the underlying molecular mechanisms are poorly understood and...
3.
Kotzampasi D, Premeti K, Papafotika A, Syropoulou V, Christoforidis S, Cournia Z, et al.
Comput Struct Biotechnol J
. 2022 Oct;
20:5607-5621.
PMID: 36284707
The oncogene PI3Kα and the tumor suppressor PTEN represent two antagonistic enzymatic activities that regulate the interconversion of the phosphoinositide lipids PI(4,5)P and PI(3,4,5)P in membranes. As such, they are...
4.
Papadopoulos C, Fotou E, Moussis V, Ntoyhaniari A, Zografou S, Maltabe V, et al.
J Pept Sci
. 2021 Jun;
27(11):e3359.
PMID: 34131994
The generation of cell-penetrating peptides as cargo-delivery systems has produced an immense number of studies owing to the importance of these systems as tools to deliver molecules into the cells,...
5.
Basagiannis D, Zografou S, Goula E, Gkeka D, Kolettas E, Christoforidis S
Cells
. 2021 Apr;
10(5).
PMID: 33922806
VEGFR2 is the main receptor and mediator of the vasculogenic and angiogenic activity of VEGF. Activated VEGFR2 internalizes through clathrin-mediated endocytosis and macropinocytosis. As dynamin is a key regulator of...
6.
Basagiannis D, Zografou S, Galanopoulou K, Christoforidis S
Sci Rep
. 2017 Mar;
7:45035.
PMID: 28327657
VEGFR2 is a critical angiogenic receptor playing a key role in vascular homeostasis. Upon activation by VEGF, VEGFR2 becomes endocytosed. Internalisation of VEGFR2 is facilitated, in part, through clathrin mediated...
7.
Martzoukou O, Amillis S, Zervakou A, Christoforidis S, Diallinas G
Elife
. 2017 Feb;
6.
PMID: 28220754
Filamentous fungi provide excellent systems for investigating the role of the AP-2 complex in polar growth. Using we show that AP-2 has a clathrin-independent essential role in polarity maintenance and...
8.
Argyros O, Lougiakis N, Kouvari E, Papafotika A, Raptopoulou C, Psycharis V, et al.
Eur J Med Chem
. 2016 Dec;
126:954-968.
PMID: 28006668
Breast cancer (BrCa) remains an unmet medical need despite the revolutionary development of antibody treatments and protein kinase inhibitors. In the current study, a series of novel substituted pyridopyrazine derivatives...
9.
Daniilides K, Lougiakis N, Evangelidis T, Kostakis I, Pouli N, Marakos P, et al.
Anticancer Agents Med Chem
. 2016 Dec;
17(7):990-1002.
PMID: 27928955
Objective: A series of novel 2,4-diaminosubstituted pyrrolo[3,2-d]pyrimidines was synthesized together with their corresponding 7-phenyl or 7-isopropyl counterparts. Results: Among the target derivatives, the 7-substituted analogues exhibited interesting cytotoxic activity against...
10.
Basagiannis D, Zografou S, Murphy C, Fotsis T, Morbidelli L, Ziche M, et al.
J Cell Sci
. 2016 Sep;
129(21):4091-4104.
PMID: 27656109
Endocytosis plays a crucial role in receptor signalling. VEGFR2 (also known as KDR) and its ligand VEGFA are fundamental in neovascularisation. However, our understanding of the role of endocytosis in...