Saumya Anang
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Explore the profile of Saumya Anang including associated specialties, affiliations and a list of published articles.
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25
Citations
446
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Recent Articles
1.
Qi Y, Zhang S, Wang K, Ding H, Zhang Z, Anang S, et al.
Commun Biol
. 2025 Mar;
8(1):442.
PMID: 40089599
During human immunodeficiency virus (HIV-1) entry, the metastable pretriggered envelope glycoprotein (Env) trimer ((gp120/gp41)) opens asymmetrically. We present cryo-EM structures of cleaved asymmetric Env trimers in amphipol-lipid nanodiscs. The gp41...
2.
Ding H, Nguyen H, Li W, Deshpande A, Zhang S, Jiang F, et al.
J Virol
. 2024 Nov;
98(12):e0172024.
PMID: 39508605
During the process by which human immunodeficiency virus (HIV-1) enters cells, the envelope glycoprotein (Env) trimer on the virion surface engages host cell receptors. Binding to the receptor CD4 induces...
3.
Zhang Z, Anang S, Wang Q, Nguyen H, Chen H, Chiu T, et al.
bioRxiv
. 2024 Nov;
PMID: 39484577
During human immunodeficiency virus (HIV-1) entry into host cells, binding to the receptors, CD4 and CCR5/CXCR4, triggers conformational changes in the metastable envelope glycoprotein (Env) trimer ((gp120-gp41)). CD4 binding induces...
4.
Zhang S, Anang S, Zhang Z, Nguyen H, Ding H, Kappes J, et al.
J Virol
. 2024 Sep;
98(10):e0063124.
PMID: 39248459
Upon binding to the host cell receptor, CD4, the pretriggered (State-1) conformation of the human immunodeficiency virus (HIV-1) envelope glycoprotein (Env) trimer undergoes transitions to downstream conformations important for virus...
5.
Zhang Z, Anang S, Nguyen H, Fritschi C, Smith 3rd A, Sodroski J
iScience
. 2024 Jul;
27(7):110141.
PMID: 38979012
The pretriggered conformation of the human immunodeficiency virus (HIV-1) envelope glycoprotein (Env) trimer ((gp120/gp41)) is targeted by virus entry inhibitors and broadly neutralizing antibodies (bNAbs). The lability of pretriggered Env...
6.
Anang S, Zhang S, Fritschi C, Chiu T, Yang D, Smith Iii A, et al.
J Virol
. 2023 Oct;
97(11):e0117123.
PMID: 37888980
CD4-mimetic compounds (CD4mcs) are small-molecule inhibitors of human immunodeficiency virus (HIV-1) entry into host cells. CD4mcs target a pocket on the viral envelope glycoprotein (Env) spike that is used for...
7.
Fritschi C, Anang S, Gong Z, Mohammadi M, Richard J, Bourassa C, et al.
Proc Natl Acad Sci U S A
. 2023 Mar;
120(13):e2222073120.
PMID: 36961924
Binding to the host cell receptors, CD4 and CCR5/CXCR4, triggers large-scale conformational changes in the HIV-1 envelope glycoprotein (Env) trimer [(gp120/gp41)] that promote virus entry into the cell. CD4-mimetic compounds...
8.
Nguyen H, Wang Q, Anang S, Sodroski J
J Virol
. 2023 Feb;
97(3):e0185722.
PMID: 36815832
Human immunodeficiency virus (HIV-1) entry into cells involves triggering of the viral envelope glycoprotein (Env) trimer ([gp120/gp41]) by the primary receptor, CD4, and coreceptors, CCR5 or CXCR4. The pretriggered (State-1)...
9.
Chaplain C, Fritschi C, Anang S, Gong Z, Richard J, Bourassa C, et al.
ACS Med Chem Lett
. 2023 Jan;
14(1):51-58.
PMID: 36655122
The human immunodeficiency virus (HIV-1) envelope glycoprotein (Env) trimer on the virion surface interacts with the host receptors, CD4 and CCR5/CXCR4, to mediate virus entry into the target cell. CD4-mimetic...
10.
Anang S, Richard J, Bourassa C, Goyette G, Chiu T, Chen H, et al.
J Virol
. 2022 Aug;
96(17):e0063622.
PMID: 35980207
Binding to the host cell receptors CD4 and CCR5/CXCR4 triggers conformational changes in the human immunodeficiency virus (HIV-1) envelope glycoprotein (Env) trimer that promote virus entry. CD4 binding allows the...