Satoshi Harashima
Overview
Explore the profile of Satoshi Harashima including associated specialties, affiliations and a list of published articles.
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Articles
81
Citations
662
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Recent Articles
1.
Hirota S, Nakayama Y, Ekino K, Harashima S
J Biosci Bioeng
. 2023 Dec;
137(2):77-84.
PMID: 38135639
Polyploid (2n, 3n, and 4n) genomes are known to be unstable in Saccharomyces cerevisiae. Here, we attempted construction of super-polypoid strains (defined as having higher ploidy than tetraploidy) up to...
2.
Hotta N, Kotaka A, Matsumura K, Sasano Y, Hata Y, Harada T, et al.
J Biosci Bioeng
. 2023 Nov;
137(1):24-30.
PMID: 37989703
Chromosome aneuploidy is a common phenomenon in industrial yeast. Aneuploidy is considered one of the strategies to enhance the industrial properties of Saccharomyces cerevisiae strains. However, the effects of chromosomal...
3.
Hirota S, Nakayama Y, Itokazu H, Ekino K, Nishizawa M, Harashima S
J Biosci Bioeng
. 2022 Apr;
133(6):515-523.
PMID: 35393168
How ploidy is determined in organisms is an important issue in bioscience. Polyploidy is believed to be relevant to useful traits of domesticated plants and microorganisms. As such, polyploidy is...
4.
Sasano Y, Harashima S
Bio Protoc
. 2021 Sep;
7(10):e2306.
PMID: 34541068
Chromosome engineering is an important technology with applications in basic biology and biotechnology. Chromosome splitting technology called PCS (PCR-mediated Chromosome Splitting) has already been developed as a fundamental chromosome engineering...
5.
Hassan N, Easmin F, Ekino K, Harashima S
Bio Protoc
. 2021 Jul;
11(13):e4082.
PMID: 34327279
Nowadays, CRISPR (clustered regularly interspaced short palindromic repeats) and the CRISPR-associated protein (Cas9) system play a major role in genome editing. To target the desired sequence of the genome successfully,...
6.
Hassan N, Easmin F, Sasano Y, Ekino K, Taguchi H, Harashima S
AMB Express
. 2020 Apr;
10(1):73.
PMID: 32296956
Previously, we identified 49 undeletable chromosomal regions harboring only non-essential genes in the genome of Saccharomyces cerevisiae. We proposed that there might be unknown synthetic lethal combinations of genes present...
7.
Hassan N, Sasano Y, Kimura S, Easmin F, Ekino K, Taguchi H, et al.
AMB Express
. 2020 Feb;
10(1):27.
PMID: 32016717
In our previous study, a novel genome engineering technology, PCR-mediated chromosome duplication (PCDup), was developed in Saccharomyces cerevisiae that enabled the duplication of any desired chromosomal region, resulting in a...
8.
Easmin F, Sasano Y, Kimura S, Hassan N, Ekino K, Taguchi H, et al.
J Biosci Bioeng
. 2019 Oct;
129(2):129-139.
PMID: 31585858
Genome manipulation, especially the deletion or replacement of chromosomal regions, is a salient tool for the analysis of genome function. Because of low homologous recombination activity, however, current methods are...
9.
Easmin F, Hassan N, Sasano Y, Ekino K, Taguchi H, Harashima S
J Biosci Bioeng
. 2019 Apr;
128(3):373-378.
PMID: 31010727
The clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR-associated protein 9 (CRISPR/Cas9) system is one of the most powerful tools for genome engineering. However, some of the steps are...
10.
Sasano Y, Sakata T, Okusaki S, Sugiyama M, Kaneko Y, Harashima S
Genes Genet Syst
. 2018 Nov;
93(5):199-207.
PMID: 30449767
To achieve inorganic phosphate (Pi) homeostasis, cells must be able to sense intracellular and extracellular Pi concentrations. In the Pi signaling (PHO) pathway in Saccharomyces cerevisiae, high Pi represses genes...