Saritha Krishna
Overview
Explore the profile of Saritha Krishna including associated specialties, affiliations and a list of published articles.
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Articles
17
Citations
262
Followers
0
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Recent Articles
1.
Gonzales C, Negussie M, Krishna S, Ambati V, Hervey-Jumper S
Trends Cancer
. 2024 Sep;
10(12):1106-1115.
PMID: 39327186
Tumor-associated epilepsy is the most common presenting symptom in patients diagnosed with diffuse gliomas. Recent evidence illustrates the requirement of synaptic activity to drive glioma proliferation and invasion. Class 1,...
2.
Drexler R, Khatri R, Sauvigny T, Mohme M, Maire C, Ryba A, et al.
Nat Med
. 2024 May;
30(6):1622-1635.
PMID: 38760585
Neural-tumor interactions drive glioma growth as evidenced in preclinical models, but clinical validation is limited. We present an epigenetically defined neural signature of glioblastoma that independently predicts patients' survival. We...
3.
Drexler R, Khatri R, Sauvigny T, Mohme M, Maire C, Ryba A, et al.
bioRxiv
. 2023 Aug;
PMID: 37609137
Neural-tumor interactions drive glioma growth as evidenced in preclinical models, but clinical validation is nascent. We present an epigenetically defined neural signature of glioblastoma that independently affects patients' survival. We...
4.
Nejo T, Krishna S, Jimenez C, Yamamichi A, Young J, Lakshmanachetty S, et al.
bioRxiv
. 2023 Aug;
PMID: 37577659
Neuronal activity-driven mechanisms impact glioblastoma cell proliferation and invasion , and glioblastoma remodels neuronal circuits . Distinct intratumoral regions maintain functional connectivity via a subpopulation of malignant cells that mediate...
5.
Krishna S, Choudhury A, Keough M, Seo K, Ni L, Kakaizada S, et al.
Nature
. 2023 May;
617(7961):599-607.
PMID: 37138086
Gliomas synaptically integrate into neural circuits. Previous research has demonstrated bidirectional interactions between neurons and glioma cells, with neuronal activity driving glioma growth and gliomas increasing neuronal excitability. Here we...
6.
Krishna S, Hervey-Jumper S
Adv Biol (Weinh)
. 2022 Jul;
6(9):e2200047.
PMID: 35802914
In recent years, there have been significant advances in understanding the neuronal influence on the biology of solid tumors such as prostate, pancreatic, gastric, and brain cancers. An increasing amount...
7.
Kaur J, Egladyous A, Valdivia C, Daniel A, Krishna S, Aabedi A, et al.
Cancers (Basel)
. 2022 Feb;
14(3).
PMID: 35158959
Language, cognition, and behavioral testing have become a fundamental component of standard clinical care for brain cancer patients. Many existing publications have identified and addressed potential ethical issues that are...
8.
Aabedi A, Lipkin B, Kaur J, Kakaizada S, Valdivia C, Reihl S, et al.
Proc Natl Acad Sci U S A
. 2021 Nov;
118(46).
PMID: 34753819
Recent developments in the biology of malignant gliomas have demonstrated that glioma cells interact with neurons through both paracrine signaling and electrochemical synapses. Glioma-neuron interactions consequently modulate the excitability of...
9.
Aabedi A, Kakaizada S, Young J, Kaur J, Wiese O, Valdivia C, et al.
Sci Rep
. 2021 Mar;
11(1):6305.
PMID: 33737672
Lexical retrieval requires selecting and retrieving the most appropriate word from the lexicon to express a desired concept. Few studies have probed lexical retrieval with tasks other than picture naming,...
10.
Krishna S, Kakaizada S, Almeida N, Brang D, Hervey-Jumper S
Neurosurgery
. 2021 Jan;
89(4):539-548.
PMID: 33476391
Gliomas exist within the framework of complex neuronal circuitry in which network dynamics influence both tumor biology and cognition. The generalized impairment of cognition or loss of language function is...