Sarah Sirin
Overview
Explore the profile of Sarah Sirin including associated specialties, affiliations and a list of published articles.
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Articles
4
Citations
110
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0
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Recent Articles
1.
Sirin S, Apgar J, Bennett E, Keating A
Protein Sci
. 2015 Oct;
25(2):393-409.
PMID: 26473627
Antibodies (Abs) are a crucial component of the immune system and are often used as diagnostic and therapeutic agents. The need for high-affinity and high-specificity antibodies in research and medicine...
2.
Gannavaram S, Sirin S, Sherman W, Gadda G
Biochemistry
. 2014 Sep;
53(41):6574-83.
PMID: 25243743
The flavin-mediated enzymatic oxidation of a CN bond in amino acids can occur through hydride transfer, carbanion, or polar nucleophilic mechanisms. Previous results with D-arginine dehydrogenase from Pseudomonas aeruginosa (PaDADH)...
3.
Sirin S, Pearlman D, Sherman W
Proteins
. 2014 Sep;
82(12):3397-409.
PMID: 25243583
Computational enzyme design is an emerging field that has yielded promising success stories, but where numerous challenges remain. Accurate methods to rapidly evaluate possible enzyme design variants could provide significant...
4.
Sirin S, Kumar R, Martinez C, Karmilowicz M, Ghosh P, Abramov Y, et al.
J Chem Inf Model
. 2014 Jul;
54(8):2334-46.
PMID: 25005922
Enzyme design is an important area of ongoing research with a broad range of applications in protein therapeutics, biocatalysis, bioengineering, and other biomedical areas; however, significant challenges exist in the...