Sarah Mangles
Overview
Explore the profile of Sarah Mangles including associated specialties, affiliations and a list of published articles.
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Articles
16
Citations
107
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0
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Recent Articles
1.
Pipe M.D S, Pipe S, Lissitchkov T, Lissitchkov T, Georgiev P, Mangles S, et al.
Blood Adv
. 2024 Dec;
9(5):1147-1158.
PMID: 39642315
Fitusiran is an investigational small interfering RNA therapeutic that targets antithrombin (AT) to rebalance hemostasis in people with hemophilia. Here, we present the results of a completed phase 2 open-label...
2.
Boyce S, Fletcher S, Jones A, Kohli R, Mangles S, Ong M, et al.
Orphanet J Rare Dis
. 2023 Nov;
18(1):366.
PMID: 38007560
With the first gene therapies for haemophilia approved by the European Commission, the US Food and Drug Administration, and the Medicines and Healthcare products Regulatory Agency, it is important to...
3.
Stanford S, Roy A, Rea C, Harris B, Ashton A, Mangles S, et al.
PLoS One
. 2023 Jan;
18(1):e0269738.
PMID: 36607961
Introduction: Abnormal coagulation and inflammation are hallmarks of SARs-COV-19. Stratifying affected patients on admission to hospital may help identify those who at are risk of developing severe disease early on....
4.
Lim D, Mangles S, Goturu A
BMJ Case Rep
. 2022 Oct;
15(10).
PMID: 36207057
A term Caucasian neonate with an uncomplicated birth history presented with persistent umbilical stump bleeding unresponsive to extensive topical haemostatic measures initially. He subsequently developed hypovolaemic shock. Routine full blood...
5.
Curry N, Bowles L, Clark T, Lowe G, Mainwaring J, Mangles S, et al.
Haemophilia
. 2022 Aug;
28(6):917-937.
PMID: 35976756
Women with inherited bleeding disorders (IBDs) may present to healthcare professionals in a variety of ways and commonly will be encountered by either haematology or gynaecology services. Heavy menstrual bleeding...
6.
Taylor S, David J, Partington K, Pemberton S, Mangles S, Wells A, et al.
Haemophilia
. 2022 Jul;
28(6):e181-e188.
PMID: 35905300
Aims: Ankle arthropathy commonly affects persons with haemophilia (PWH). Joint damage causes loss of movement, pain and reduced function. Current treatments are limited. Viscosupplementation has been used to treat other...
7.
Boyce S, James I, Rangarajan S, Curry N, Bagot C, Austin S, et al.
Res Pract Thromb Haemost
. 2022 Jun;
6(4):e12705.
PMID: 35677030
Background: Gene therapy shows promise as a potential "cure" for hemophilia A and B. Adeno-associated virus (AAV) vectors are the leading platform to deliver modified genetic code of factor VIII...
8.
St-Louis J, Abad A, Funk S, Tilak M, Classey S, Zourikian N, et al.
Res Pract Thromb Haemost
. 2022 Mar;
6(2):e12690.
PMID: 35356667
Background: The Hemophilia Joint Health Score (HJHS) was developed and validated to detect arthropathy in children. Additional evidence is required to show validity in adults. We studied the convergent and...
9.
Shapiro S, Benson G, Evans G, Harrison C, Mangles S, Makris M
Br J Haematol
. 2022 Feb;
197(4):397-406.
PMID: 35191019
The development of effective and safe treatments has significantly increased the life expectancy of persons with haemophilia (PWH). This has been accompanied by an increase in the comorbidities of ageing...
10.
Wells A, Whitaker S, Gray D, Mangles S, Hislop-Lennie K, Stephensen D
Haemophilia
. 2021 Dec;
28(2):e46-e48.
PMID: 34951513
No abstract available.