Sarah Jacobson
Overview
Explore the profile of Sarah Jacobson including associated specialties, affiliations and a list of published articles.
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Articles
15
Citations
422
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0
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Recent Articles
1.
Venkatesh A, McKenty T, Ali S, Sonntag D, Ravipaty S, Cui Y, et al.
Nucleic Acid Ther
. 2024 Sep;
34(5):221-233.
PMID: 39264859
Autosomal dominant optic atrophy (ADOA) is an inherited optic neuropathy most frequently associated with mutations. Most variants result in haploinsufficiency, and patient cells express roughly half of the normal levels...
2.
Correia S, Liu G, Jacobson S, Bernier S, Tobin J, Schwartzkopf C, et al.
J Neuroinflammation
. 2021 Sep;
18(1):213.
PMID: 34537066
Background: Inflammation in the central nervous system (CNS) is observed in many neurological disorders. Nitric oxide-soluble guanylate cyclase-cyclic guanosine monophosphate (NO-sGC-cGMP) signaling plays an essential role in modulating neuroinflammation. CYR119...
3.
Correia S, Iyengar R, Germano P, Tang K, Bernier S, Schwartzkopf C, et al.
Front Pharmacol
. 2021 Jun;
12:656561.
PMID: 34108877
Effective treatments for neurodegenerative diseases remain elusive and are critically needed since the burden of these diseases increases across an aging global population. Nitric oxide (NO) is a gasotransmitter that...
4.
Zimmer D, Shea C, Tobin J, Tchernychev B, Germano P, Sykes K, et al.
Front Pharmacol
. 2020 Apr;
11:419.
PMID: 32322204
Nitric oxide (NO)-soluble guanylate cyclase (sGC)-cyclic 3',5' GMP (cGMP) signaling plays a central role in regulation of diverse processes including smooth muscle relaxation, inflammation, and fibrosis. sGC is activated by...
5.
Hall K, Bernier S, Jacobson S, Liu G, Zhang P, Sarno R, et al.
Proc Natl Acad Sci U S A
. 2019 May;
116(22):11057-11062.
PMID: 31085647
Endothelial dysfunction and reduced nitric oxide (NO) signaling are a key element of the pathophysiology of nonalcoholic steatohepatitis (NASH). Stimulators of soluble guanylate cyclase (sGC) enhance NO signaling; have been...
6.
Tobin J, Zimmer D, Shea C, Germano P, Bernier S, Liu G, et al.
J Pharmacol Exp Ther
. 2018 Apr;
365(3):664-675.
PMID: 29643251
Soluble guanylate cyclase (sGC), a key signal-transduction enzyme, increases the conversion of guanosine-5'-triphosphate to cGMP upon binding of nitric oxide (NO). Endothelial dysfunction and/or reduced NO signaling have been implicated...
7.
Eid N, OHagan A, Bickel S, Morton R, Jacobson S, Myers J
J Asthma Allergy
. 2016 Oct;
9:183-189.
PMID: 27785078
Background: Low-dose theophylline has been recognized for its ability to restore histone deacetylase-2 activity which leads to improved steroid responsiveness and thus improved clinical outcome. We retrospectively evaluated the effect...
8.
Castro J, Harrington A, Hughes P, Martin C, Ge P, Shea C, et al.
Gastroenterology
. 2013 Aug;
145(6):1334-46.e1-11.
PMID: 23958540
Background & Aims: Linaclotide is a minimally absorbed agonist of guanylate cyclase-C (GUCY2C or GC-C) that reduces symptoms associated with irritable bowel syndrome with constipation (IBS-C). Little is known about...
9.
Silos-Santiago I, Hannig G, Eutamene H, Ustinova E, Bernier S, Ge P, et al.
Pain
. 2013 Jun;
154(9):1820-1830.
PMID: 23748116
The natural hormone uroguanylin regulates intestinal fluid homeostasis and bowel function through activation of guanylate cyclase-C (GC-C), resulting in increased intracellular cyclic guanosine-3',5'-monophosphate (cGMP). We report the effects of uroguanylin-mediated...
10.
Rose E, Greene C, Kelly S, Morris D, Robertson I, Fahey C, et al.
Neuroimage
. 2012 Jan;
60(1):614-22.
PMID: 22227051
A common polymorphism within the nitric oxide sythanse-1 (NOS1) gene (rs6490121), initially identified as risk variant for schizophrenia, has been associated with variation in working memory and IQ. Here we...