Sarah Arbe-Barnes
Overview
Explore the profile of Sarah Arbe-Barnes including associated specialties, affiliations and a list of published articles.
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Snapshot
Articles
13
Citations
464
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0
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Recent Articles
11.
Moehrle J, Duparc S, Siethoff C, van Giersbergen P, Craft J, Arbe-Barnes S, et al.
Br J Clin Pharmacol
. 2012 Jul;
75(2):524-37.
PMID: 22759078
Aims: To assess the safety and pharmacokinetics of a new synthetic ozonide antimalarial, OZ439, in a first-in-man, double-blind study in healthy volunteers. Methods: OZ439 was administered as single oral daily...
12.
Charman S, Arbe-Barnes S, Bathurst I, Brun R, Campbell M, Charman W, et al.
Proc Natl Acad Sci U S A
. 2011 Feb;
108(11):4400-5.
PMID: 21300861
Ozonide OZ439 is a synthetic peroxide antimalarial drug candidate designed to provide a single-dose oral cure in humans. OZ439 has successfully completed Phase I clinical trials, where it was shown...
13.
Kocken C, van der Wel A, Arbe-Barnes S, Brun R, Matile H, Scheurer C, et al.
Exp Parasitol
. 2006 Feb;
113(3):197-200.
PMID: 16458301
Plasmodium vivax is an important human pathogen causing malaria in more temperate climates of the world. Similar to Plasmodium falciparum, the causative agent for malaria tropica, drug resistance is beginning...
14.
Vennerstrom J, Arbe-Barnes S, Brun R, Charman S, Chiu F, Chollet J, et al.
Nature
. 2004 Aug;
430(7002):900-4.
PMID: 15318224
The discovery of artemisinin more than 30 years ago provided a completely new antimalarial structural prototype; that is, a molecule with a pharmacophoric peroxide bond in a unique 1,2,4-trioxane heterocycle....