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Sarah A Slavoff

Explore the profile of Sarah A Slavoff including associated specialties, affiliations and a list of published articles. Areas
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Articles 37
Citations 1659
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Recent Articles
1.
Wacholder A, Deutsch E, Kok L, van Dinter J, Lee J, Wright J, et al.
bioRxiv . 2025 Mar; PMID: 40027765
Thousands of short open reading frames (sORFs) are translated outside of annotated coding sequences. Recent studies have pioneered searching for sORF-encoded microproteins in mass spectrometry (MS)-based proteomics and peptidomics datasets....
2.
Su H, Katz S, Slavoff S
bioRxiv . 2024 Nov; PMID: 39484585
Overlapping genes were thought to be essentially absent from the human genome until the discovery of abundant, frameshifted internal open reading frames (iORFs) nested within annotated protein coding sequences. However,...
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Deutsch E, Kok L, Mudge J, Ruiz-Orera J, Fierro-Monti I, Sun Z, et al.
bioRxiv . 2024 Sep; PMID: 39314370
A major scientific drive is to characterize the protein-coding genome as it provides the primary basis for the study of human health. But the fundamental question remains: what has been...
4.
Mohsen J, Mohsen M, Jiang K, Landajuela A, Quinto L, Isaacs F, et al.
bioRxiv . 2024 Jul; PMID: 38979229
Over the past 15 years, hundreds of previously undiscovered bacterial small open reading frame (sORF)-encoded polypeptides (SEPs) of fewer than fifty amino acids have been identified, and biological functions have...
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Sappakhaw K, Jantarug K, Slavoff S, Israsena N, Uttamapinant C
Angew Chem Weinheim Bergstr Ger . 2024 Mar; 133(8):3980-3985. PMID: 38504667
Polypeptides generated from proteolytic processing of protein precursors, or proteolytic proteoforms, play an important role in diverse biological functions and diseases. However, their often-small size and intricate post-translational biogenesis preclude...
6.
Chen Y, Su H, Zhao J, Na Z, Jiang K, Bacchiocchi A, et al.
Cell Rep . 2023 Sep; 42(9):113145. PMID: 37725512
The conserved WD40-repeat protein WDR5 interacts with multiple proteins both inside and outside the nucleus. However, it is currently unclear whether and how the distribution of WDR5 between complexes is...
7.
Mohsen J, Martel A, Slavoff S
Proteomics . 2023 Aug; 23(23-24):e2100211. PMID: 37603371
Advances in proteogenomic technologies have revealed hundreds to thousands of translated small open reading frames (sORFs) that encode microproteins in genomes across evolutionary space. While many microproteins have now been...
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Mohsen J, Slavoff S
Mol Cell . 2023 Jun; 83(12):1967-1969. PMID: 37327774
Translation of noncoding regions is ubiquitous and upregulated in disease. Kesner et al. elucidate the mechanism by which the BAG6 complex exerts quality control over noncoding translation while targeting stable,...
10.
Chen Y, Cao X, Loh K, Slavoff S
Biochem Soc Trans . 2023 May; 51(3):1071-1082. PMID: 37171061
Thousands of unannotated small and alternative open reading frames (smORFs and alt-ORFs, respectively) have recently been revealed in mammalian genomes. While hundreds of mammalian smORF- and alt-ORF-encoded proteins (SEPs and...