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Sara Zaccara

Explore the profile of Sara Zaccara including associated specialties, affiliations and a list of published articles. Areas
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Articles 18
Citations 3030
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Recent Articles
1.
Elvira-Blazquez D, Fernandez-Justel J, Arcas A, Statello L, Goni E, Gonzalez J, et al.
EMBO J . 2024 Jul; 43(16):3494-3522. PMID: 38951610
Cells have evolved a robust and highly regulated DNA damage response to preserve their genomic integrity. Although increasing evidence highlights the relevance of RNA regulation, our understanding of its impact...
2.
Zaccara S, Jaffrey S
RNA . 2024 Mar; 30(5):468-481. PMID: 38531646
-methyladenosine (mA) is the most prevalent modified nucleotide in mRNA, and it has important functions in mRNA regulation. However, our understanding of the specific functions of mA along with its...
3.
Zaccara S, Ries R, Jaffrey S
Nat Rev Mol Cell Biol . 2023 Aug; 24(10):770. PMID: 37604996
No abstract available.
4.
Micaelli M, Dalle Vedove A, Cerofolini L, Vigna J, Sighel D, Zaccara S, et al.
ACS Pharmacol Transl Sci . 2022 Oct; 5(10):872-891. PMID: 36268123
YTHDF proteins bind the -methyladenosine (m6A)-modified mRNAs, influencing their processing, stability, and translation. Therefore, the members of this protein family play crucial roles in gene regulation and several physiological and...
5.
Valentini S, Marchioretti C, Bisio A, Rossi A, Zaccara S, Romanel A, et al.
iScience . 2021 Dec; 24(12):103531. PMID: 34917903
Few studies have explored the association between SNPs and alterations in mRNA translation potential. We developed an approach to identify SNPs that can mark allele-specific protein expression levels and could...
6.
Rizzotto D, Zaccara S, Rossi A, Dassi E, Inga A
Mol Cell Oncol . 2020 Sep; 7(5):1767483. PMID: 32944629
The search for mechanisms underlying different cellular responses to the treatment with Nutlin-3, an MDM2 inhibitor that unleashes p53, revealed a translational control mechanism involving the RNA binding proteins PCBP2...
7.
Zaccara S, Jaffrey S
Cell . 2020 Jun; 181(7):1582-1595.e18. PMID: 32492408
N-methyladenosine (mA) is the most abundant mRNA nucleotide modification and regulates critical aspects of cellular physiology and differentiation. mA is thought to mediate its effects through a complex network of...
8.
Rizzotto D, Zaccara S, Rossi A, Galbraith M, Andrysik Z, Pandey A, et al.
Cell Rep . 2020 Apr; 30(13):4355-4369.e6. PMID: 32234473
Activation of p53 by the small molecule Nutlin can result in a combination of cell cycle arrest and apoptosis. The relative strength of these events is difficult to predict by...
9.
Zaccara S, Ries R, Jaffrey S
Nat Rev Mol Cell Biol . 2019 Sep; 20(10):608-624. PMID: 31520073
RNA methylation to form N-methyladenosine (mA) in mRNA accounts for the most abundant mRNA internal modification and has emerged as a widespread regulatory mechanism that controls gene expression in diverse...
10.
Wu J, Zaccara S, Khuperkar D, Kim H, Tanenbaum M, Jaffrey S
Nat Methods . 2019 Sep; 16(9):862-865. PMID: 31471614
Fluorogenic RNA aptamers bind and activate the fluorescence of otherwise nonfluorescent dyes. However, fluorogenic aptamers are limited by the small number of fluorogenic dyes suitable for use in live cells....