Sara M Willems
Overview
Explore the profile of Sara M Willems including associated specialties, affiliations and a list of published articles.
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55
Citations
6674
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Recent Articles
1.
Willems S, Ng N, Fernandez J, Fine R, Wheeler E, Wessel J, et al.
Wellcome Open Res
. 2024 Sep;
8():483.
PMID: 39280063
Background: Genome-wide association studies for glycemic traits have identified hundreds of loci associated with these biomarkers of glucose homeostasis. Despite this success, the challenge remains to link variant associations to...
2.
Lagou V, Jiang L, Ulrich A, Zudina L, Gonzalez K, Balkhiyarova Z, et al.
Nat Genet
. 2023 Sep;
55(9):1448-1461.
PMID: 37679419
Conventional measurements of fasting and postprandial blood glucose levels investigated in genome-wide association studies (GWAS) cannot capture the effects of DNA variability on 'around the clock' glucoregulatory processes. Here we...
3.
Chen J, Spracklen C, Marenne G, Varshney A, Corbin L, Luan J, et al.
Nat Genet
. 2021 Jun;
53(6):840-860.
PMID: 34059833
Glycemic traits are used to diagnose and monitor type 2 diabetes and cardiometabolic health. To date, most genetic studies of glycemic traits have focused on individuals of European ancestry. Here...
4.
Surendran P, Feofanova E, Lahrouchi N, Ntalla I, Karthikeyan S, Cook J, et al.
Nat Genet
. 2021 Mar;
53(5):762.
PMID: 33727701
No abstract available.
5.
Lagou V, Magi R, Hottenga J, Grallert H, Perry J, Bouatia-Naji N, et al.
Nat Commun
. 2021 Feb;
12(1):995.
PMID: 33558525
No abstract available.
6.
Lagou V, Magi R, Hottenga J, Grallert H, Perry J, Bouatia-Naji N, et al.
Nat Commun
. 2021 Jan;
12(1):24.
PMID: 33402679
Differences between sexes contribute to variation in the levels of fasting glucose and insulin. Epidemiological studies established a higher prevalence of impaired fasting glucose in men and impaired glucose tolerance...
7.
van Zuydam N, Ladenvall C, Voight B, Strawbridge R, Fernandez-Tajes J, Rayner N, et al.
Circ Genom Precis Med
. 2020 Dec;
13(6):e002769.
PMID: 33321069
Background: Coronary artery disease (CAD) is accelerated in subjects with type 2 diabetes mellitus (T2D). Methods: To test whether this reflects differential genetic influences on CAD risk in subjects with...
8.
Surendran P, Feofanova E, Lahrouchi N, Ntalla I, Karthikeyan S, Cook J, et al.
Nat Genet
. 2020 Nov;
52(12):1314-1332.
PMID: 33230300
Genetic studies of blood pressure (BP) to date have mainly analyzed common variants (minor allele frequency > 0.05). In a meta-analysis of up to ~1.3 million participants, we discovered 106...
9.
Yaghootkar H, Zhang Y, Spracklen C, Karaderi T, Huang L, Bradfield J, et al.
Diabetes
. 2020 Sep;
69(12):2806-2818.
PMID: 32917775
Leptin influences food intake by informing the brain about the status of body fat stores. Rare mutations associated with congenital leptin deficiency cause severe early-onset obesity that can be mitigated...
10.
Spracklen C, Karaderi T, Yaghootkar H, Schurmann C, Fine R, Kutalik Z, et al.
Am J Hum Genet
. 2019 Sep;
105(3):670-671.
PMID: 31491410
No abstract available.