Sara Hughes
Overview
Explore the profile of Sara Hughes including associated specialties, affiliations and a list of published articles.
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Articles
31
Citations
1160
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Recent Articles
11.
Hughes S, Wells K, McSorley P, Freeman A
Pharm Stat
. 2014 Mar;
13(3):179-83.
PMID: 24668938
In May 2013, GlaxoSmithKline (980 Great West Road, Brentford, Middlesex, TW8 9GS, UK) established a new online system to enable scientific researchers to request access to anonymised patient level clinical...
12.
Hughes S, Harris J, Flack N, Cuffe R
Pharm Stat
. 2012 Jul;
11(5):410-6.
PMID: 22807372
Considerable statistical research has been performed in recent years to develop sophisticated statistical methods for handling missing data and dropouts in the analysis of clinical trial data. However, if statisticians...
13.
14.
Stellbrink H, Orkin C, Arribas J, Compston J, Gerstoft J, Van Wijngaerden E, et al.
Clin Infect Dis
. 2010 Sep;
51(8):963-72.
PMID: 20828304
Background: Abacavir-lamivudine and tenofovir DF-emtricitabine fixed-dose combinations are commonly used as first-line antiretroviral therapies. However, few studies have comprehensively compared their relative safety profiles. Methods: In this European, multicenter, open-label,...
15.
Bambra C, Joyce K, Bellis M, Greatley A, Greengross S, Hughes S, et al.
J Public Health (Oxf)
. 2010 May;
32(4):496-505.
PMID: 20435581
Background: In November 2008, the Secretary of State for Health (England) commissioned an independent review to propose effective strategies for reducing health inequalities. Review task groups were given just 3...
16.
Bellis M, Phillips-Howard P, Hughes K, Hughes S, Cook P, Morleo M, et al.
BMC Public Health
. 2009 Oct;
9:380.
PMID: 19818118
Background: There is a lack of empirical analyses examining how alcohol consumption patterns in children relate to harms. Such intelligence is required to inform parents, children and policy relating to...
17.
Informing the selection of futility stopping thresholds: case study from a late-phase clinical trial
Hughes S, Cuffe R, Lieftucht A, Nichols W
Pharm Stat
. 2008 Apr;
8(1):25-37.
PMID: 18383194
In an environment where (i) potential risks to subjects participating in clinical studies need to be managed carefully, (ii) trial costs are increasing, and (iii) there are limited research resources...
18.
Mallal S, Phillips E, Carosi G, Molina J, Workman C, Tomazic J, et al.
N Engl J Med
. 2008 Feb;
358(6):568-79.
PMID: 18256392
Background: Hypersensitivity reaction to abacavir is strongly associated with the presence of the HLA-B*5701 allele. This study was designed to establish the effectiveness of prospective HLA-B*5701 screening to prevent the...
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20.
Carroll K, Ross H, Evans D, France L, Hemmings R, Hughes S, et al.
Pharm Stat
. 2007 Sep;
7(4):263-9.
PMID: 17847030
The European Agency for the Evaluation of Medicinal Products has recently completed the consultation of a draft guidance on how to implement conditional approval. This route of application is available...