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Sara De Brouwer

Explore the profile of Sara De Brouwer including associated specialties, affiliations and a list of published articles. Areas
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Articles 14
Citations 497
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Recent Articles
1.
Decaesteker B, Louwagie A, Loontiens S, De Vloed F, Bekaert S, Roels J, et al.
Nat Commun . 2023 Mar; 14(1):1267. PMID: 36882421
The pediatric extra-cranial tumor neuroblastoma displays a low mutational burden while recurrent copy number alterations are present in most high-risk cases. Here, we identify SOX11 as a dependency transcription factor...
2.
Vanhauwaert S, Decaesteker B, De Brouwer S, Leonelli C, Durinck K, Mestdagh P, et al.
Sci Rep . 2019 Jun; 9(1):8360. PMID: 31164657
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper.
3.
Vanhauwaert S, Decaesteker B, De Brouwer S, Leonelli C, Durinck K, Mestdagh P, et al.
Sci Rep . 2018 Dec; 8(1):17468. PMID: 30504901
Chemotherapy resistance is responsible for high mortality rates in neuroblastoma. MYCN, an oncogenic driver in neuroblastoma, controls pluripotency genes including LIN28B. We hypothesized that enhanced embryonic stem cell (ESC) gene...
4.
Ooi C, Carter D, Liu B, Mayoh C, Beckers A, Lalwani A, et al.
Cancer Res . 2018 Apr; 78(12):3122-3134. PMID: 29610116
Neuroblastoma is a pediatric cancer of the sympathetic nervous system where amplification is a key indicator of poor prognosis. However, mechanisms by which MYCN promotes neuroblastoma tumorigenesis are not fully...
5.
Lambertz I, Kumps C, Claeys S, Lindner S, Beckers A, Janssens E, et al.
Clin Cancer Res . 2015 Mar; 21(14):3327-39. PMID: 25805801
Purpose: Activating ALK mutations are present in almost 10% of primary neuroblastomas and mark patients for treatment with small-molecule ALK inhibitors in clinical trials. However, recent studies have shown that...
6.
Rihani A, Van Goethem A, Ongenaert M, De Brouwer S, Volders P, Agarwal S, et al.
Sci Rep . 2015 Mar; 5:9027. PMID: 25762502
Restoration of the antitumor activity of p53 could offer a promising approach for the treatment of neuroblastoma. MicroRNAs (miRNAs) are important mediators of p53 activity, but their role in the...
7.
Bustin S, Benes V, Garson J, Hellemans J, Huggett J, Kubista M, et al.
Nat Methods . 2013 Nov; 10(11):1063-7. PMID: 24173381
Two surveys of over 1,700 publications whose authors use quantitative real-time PCR (qPCR) reveal a lack of transparent and comprehensive reporting of essential technical information. Reporting standards are significantly improved...
8.
Rihani A, Van Maerken T, Pattyn F, Van Peer G, Beckers A, De Brouwer S, et al.
PLoS One . 2013 Aug; 8(8):e71776. PMID: 23977142
Background: Measuring messenger RNA (mRNA) levels using the reverse transcription quantitative polymerase chain reaction (RT-qPCR) is common practice in many laboratories. A specific set of mRNAs as internal control reference...
9.
Kumps C, Fieuw A, Mestdagh P, Menten B, Lefever S, Pattyn F, et al.
PLoS One . 2013 Jan; 8(1):e52321. PMID: 23308108
Neuroblastoma is an embryonic tumor arising from immature sympathetic nervous system cells. Recurrent genomic alterations include MYCN and ALK amplification as well as recurrent patterns of gains and losses of...
10.
Lammens T, Swerts K, Derycke L, De Craemer A, De Brouwer S, De Preter K, et al.
PLoS One . 2012 Feb; 7(2):e31206. PMID: 22355346
One of the first and most important steps in the metastatic cascade is the loss of cell-cell and cell-matrix interactions. N-cadherin, a crucial mediator of homotypic and heterotypic cell-cell interactions,...