Sara Bohnert
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Explore the profile of Sara Bohnert including associated specialties, affiliations and a list of published articles.
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Articles
8
Citations
36
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Recent Articles
1.
Hmidan Simsam M, Delorme L, Grimm D, Priestap F, Bohnert S, Descoteaux M, et al.
Injury
. 2023 Feb;
54(3):857-870.
PMID: 36746710
Background: Standard dose (≤ 1 g) tranexamic acid (TXA) has established mortality benefit in trauma patients. The role of high dose IV TXA (≥2 g or ≥30 mg/kg as a...
2.
Kentrop J, Savransky V, Klaassen S, van Groningen T, Bohnert S, Cornelissen A, et al.
Regul Toxicol Pharmacol
. 2020 Nov;
119:104823.
PMID: 33212192
Nerve agent exposure is generally treated by an antidote formulation composed of a muscarinic antagonist, atropine sulfate (ATR), and a reactivator of acetylcholinesterase (AChE) such as pralidoxime, obidoxime (OBI), methoxime,...
3.
Lee K, Bohnert S, Vair C, Mikler J, Dunn J
Toxicol Lett
. 2020 Nov;
336:50-56.
PMID: 33147512
Nerve agent exposure can cause debilitating neurological damage even with treatment. Currently accepted treatments involve attenuating the cholinergic crisis and seizure onset but do not focus directly on neuroprotection. Hence,...
4.
Lee K, Bohnert S, Bouchard M, Vair C, Farrell J, Teskey G, et al.
Sci Rep
. 2020 Aug;
10(1):13007.
PMID: 32747689
Organophosphorus compounds, such as chemical warfare nerve agents and pesticides, are known to cause neurological damage. This study measured nerve agent-related neuropathology and determined whether quantitative T MRI could be...
5.
Cornelissen A, Klaassen S, van Groningen T, Bohnert S, Joosen M
Toxicol Appl Pharmacol
. 2020 Apr;
396:114994.
PMID: 32251685
Anticholinergic treatment is key for effective medical treatment of nerve agent exposure. Atropine is included at a 2 mg intramuscular dose in so-called autoinjectors designed for self- and buddy-aid. As...
6.
Bohnert S, van den Berg R, Mikler J, Klaassen S, Joosen M
Toxicol Lett
. 2020 Jan;
324:86-94.
PMID: 31954867
Organophosphorus nerve agents (NA) inhibit acetylcholinesterase (AChE) which results in the over-stimulation of both the central and peripheral nervous systems, creating a toxic syndrome that can be lethal if left...
7.
Lee K, Bohnert S, Wu Y, Vair C, Mikler J, Teskey G, et al.
Neurotoxicology
. 2018 Jan;
65:28-37.
PMID: 29378300
Nerve agents (NAs) are potent organophosphorus (OP) compounds with applications in chemical warfare. OP compounds act by inhibiting acetylcholinesterase (AChE). Soman (O-pinacolyl methylphosphonofluoridate) is one of the most potent NAs....
8.
Bohnert S, Vair C, Mikler J
J Chromatogr B Analyt Technol Biomed Life Sci
. 2010 Apr;
878(17-18):1407-13.
PMID: 20395179
A rapid and small volume assay to quantify HI-6 in plasma was developed to further the development and licensing of an intravenous formulation of HI-6. The objective of this method...